Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3505833..3507471 Replicon chromosome
Accession NZ_CP011539
Organism Klebsiella aerogenes strain G7

Toxin (Protein)


Gene name hipA Uniprot ID A0A7U9APU8
Locus tag EAG7_RS16445 Protein ID WP_001314390.1
Coordinates 3505833..3507161 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A754E9C8
Locus tag EAG7_RS27615 Protein ID WP_001314389.1
Coordinates 3507166..3507471 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAG7_RS16425 3501810..3503294 + 1485 WP_001060567.1 chromosome partitioning protein ParB -
EAG7_RS16430 3503278..3503817 + 540 WP_000938043.1 DUF2857 domain-containing protein -
EAG7_RS16435 3503836..3504969 + 1134 WP_015368501.1 helix-turn-helix domain-containing protein -
EAG7_RS16440 3505035..3505706 - 672 WP_000863683.1 hypothetical protein -
EAG7_RS16445 3505833..3507161 - 1329 WP_001314390.1 type II toxin-antitoxin system HipA family toxin Toxin
EAG7_RS27615 3507166..3507471 - 306 WP_001314389.1 helix-turn-helix transcriptional regulator Antitoxin
EAG7_RS16450 3508022..3510334 + 2313 WP_015368502.1 autotransporter outer membrane beta-barrel domain-containing protein -
EAG7_RS16455 3510441..3511034 + 594 WP_015368503.1 hypothetical protein -
EAG7_RS16460 3511392..3512429 - 1038 WP_001230900.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 50662.34 Da        Isoelectric Point: 4.9669

>T54520 WP_001314390.1 NZ_CP011539:c3507161-3505833 [Klebsiella aerogenes]
MRRTQQRLAIWMNGIRVGFWEKARGEDSLQYLPEWVVDEQGRPLSLSLPFTPGNQLWRGNVVRDYFDNLLPDSEGIRRRL
AVRYQSESLEPFDLLAELGRDCVGAIQLLDVDEEPTDLFSVNYRPLSEADIATTLRNTTAASLPGRQDETDDLRLSIAGA
QEKTALLWHEEQWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLLLEHYGIPVAKTQIAQFEDQKALVVERF
DRRWSGDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMDILSHSDQAEQDKEQFFRAQIIFWLLAATDGHAKNFS
IAIEPQSHYHLTPLYDVLSAWPVIGHGNNQISWQRCKLAMAVRGSSNYYHIYRIQRRHWINHGELTGLGRRQVESMMDDI
ISSTPEVIERVSMLLPESFPPELAECIFEGMRQQCRRLAGRE

Download         Length: 1329 bp

>T54520 NZ_CP011539:c3507161-3505833 [Klebsiella aerogenes]
ATGCGTCGAACACAGCAGCGTTTAGCAATATGGATGAATGGAATCCGGGTCGGATTCTGGGAGAAGGCCAGAGGCGAGGA
TTCATTACAATATCTTCCAGAATGGGTAGTTGATGAACAGGGAAGACCTTTATCGCTTTCTTTGCCTTTCACTCCCGGTA
ATCAGCTTTGGCGCGGTAACGTTGTTCGTGACTATTTTGATAATTTATTGCCTGACAGCGAAGGTATACGCAGGCGTTTA
GCCGTACGTTACCAGTCTGAAAGCCTTGAGCCTTTTGATCTATTGGCTGAGCTGGGAAGAGACTGCGTTGGCGCAATACA
GTTACTGGATGTTGATGAAGAGCCCACGGATTTATTTTCCGTAAATTATCGCCCACTTTCTGAAGCTGATATAGCCACTA
CATTGCGTAATACTACGGCGGCATCGTTGCCTGGTCGGCAGGACGAAACTGACGATTTGCGTTTATCAATTGCCGGTGCG
CAGGAAAAAACGGCTTTATTGTGGCATGAAGAACAATGGTGTTTACCAGAAGGTAATACCCCAACAACGCATATCTTCAA
GCTACCGCTTGGGTTGGTTGGGAACATGCAAGCGGATATGAGTACATCGGTTGAAAATGAATGGCTGTGTTCTTTGCTTC
TTGAGCACTACGGGATCCCTGTAGCAAAAACGCAGATTGCGCAGTTTGAAGATCAAAAGGCATTAGTGGTTGAGCGTTTC
GACAGAAGATGGTCAGGCGATCGGCAATGGATCATTCGTTTGCCCCAAGAGGATATGTGTCAGGCTTTAGGTGTTTCTCC
GTTACGAAAATACCAGTCTGATGGTGGGCCGGGTATTTCCGATATTATGGACATATTGAGTCATTCAGATCAGGCTGAGC
AGGACAAAGAGCAGTTCTTCAGGGCGCAAATTATTTTCTGGTTGTTGGCTGCTACTGACGGCCATGCCAAAAATTTCAGT
ATCGCTATTGAGCCACAAAGTCATTACCACCTTACGCCTCTTTACGATGTTTTATCAGCATGGCCGGTAATTGGTCATGG
TAATAATCAGATTTCCTGGCAGAGATGCAAACTGGCAATGGCTGTTCGCGGTAGCAGTAATTATTACCACATTTATAGAA
TTCAACGGCGGCATTGGATCAATCATGGTGAATTAACCGGATTGGGAAGGCGACAAGTTGAGTCCATGATGGATGACATT
ATATCCAGCACGCCAGAAGTCATTGAGCGTGTATCTATGTTGCTTCCAGAGTCGTTTCCACCTGAGCTTGCTGAGTGTAT
TTTTGAAGGTATGCGGCAGCAGTGTAGGCGTTTGGCTGGAAGGGAATAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11363.02 Da        Isoelectric Point: 10.1481

>AT54520 WP_001314389.1 NZ_CP011539:c3507471-3507166 [Klebsiella aerogenes]
MNTVYPLKTLNQIRPLLIGFRKANGLTQKEVSERLGVTQQTYARLEANPASASMERLFRVFTVLGVEMVLSSGPQILSSM
SSSTMDESEQQKDSPARREKW

Download         Length: 306 bp

>AT54520 NZ_CP011539:c3507471-3507166 [Klebsiella aerogenes]
ATGAATACTGTTTATCCGTTGAAAACTTTGAATCAAATACGCCCATTGCTGATTGGCTTTCGCAAGGCTAATGGACTGAC
ACAAAAGGAAGTTTCTGAAAGGTTAGGAGTAACTCAGCAAACCTATGCCCGACTGGAAGCGAATCCAGCCAGTGCCAGTA
TGGAGCGACTATTCAGGGTATTTACCGTGCTGGGTGTTGAAATGGTACTCTCTTCTGGACCACAGATACTTTCCTCGATG
TCATCTTCAACAATGGATGAATCAGAACAACAAAAAGATTCACCTGCCAGAAGGGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9APU8

Antitoxin

Source ID Structure
AlphaFold DB A0A754E9C8

References