Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2849413..2850032 Replicon chromosome
Accession NZ_CP011539
Organism Klebsiella aerogenes strain G7

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag EAG7_RS13465 Protein ID WP_015367918.1
Coordinates 2849814..2850032 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag EAG7_RS13460 Protein ID WP_015367917.1
Coordinates 2849413..2849787 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAG7_RS13450 2844572..2845771 + 1200 WP_020079451.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EAG7_RS13455 2845794..2848940 + 3147 WP_015367916.1 multidrug efflux RND transporter permease subunit -
EAG7_RS13460 2849413..2849787 + 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
EAG7_RS13465 2849814..2850032 + 219 WP_015367918.1 hemolysin expression modulator Hha Toxin
EAG7_RS13470 2850164..2850727 + 564 WP_015367919.1 maltose O-acetyltransferase -
EAG7_RS13475 2850853..2851317 + 465 WP_015367920.1 YlaC family protein -
EAG7_RS13480 2851292..2852746 - 1455 WP_015367921.1 PLP-dependent aminotransferase family protein -
EAG7_RS13485 2852849..2853559 + 711 WP_015367922.1 GNAT family N-acetyltransferase -
EAG7_RS13490 2853556..2853696 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
EAG7_RS13495 2853699..2853959 - 261 WP_015367923.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2849413..2860015 10602


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T54519 WP_015367918.1 NZ_CP011539:2849814-2850032 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T54519 NZ_CP011539:2849814-2850032 [Klebsiella aerogenes]
ATGTCTGGTAAACCATTAACTAAAACAGACTATTTGATGCGTTTACGCCGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAGAATAAATATGAACTTTCCGACAATGAATTGGCGGTATTTTACTCAGCAGCCGACCATCGTCTTGCTGAAT
TGACCATGAATAAGCTATACGACAAAATCCCAACTTCAGTATGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT54519 WP_015367917.1 NZ_CP011539:2849413-2849787 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT54519 NZ_CP011539:2849413-2849787 [Klebsiella aerogenes]
ATGGACGAGTACTCGCCAAAAAGACATGATATCGCGCAGCTAAGATTTCTCTGCGAAACGTTGTATCATGACTGCCTTGC
AAACCTGGAAGAAAGCAACCGCGGCTGGGTTAACGATCCCACCTCGGCGGTGAATCTTCAATTAAATGAATTGATCGAGC
ACATAGCAACTTACGCGCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATTTCTCAGCTTGATGAATACCTG
GATGACACTTTTATGCTGTTCAGTAGCTATGGCATAAACACAAGCGATCTCCAAAAATGGCGCAAATCCGGCAATCGGTT
ATTCCGATGCTTTGTGAACGCCAGCCGGGAGAACCCGGCAAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References