Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1533347..1534086 Replicon chromosome
Accession NZ_CP011539
Organism Klebsiella aerogenes strain G7

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag EAG7_RS07255 Protein ID WP_032705770.1
Coordinates 1533601..1534086 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag EAG7_RS07250 Protein ID WP_015366659.1
Coordinates 1533347..1533613 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAG7_RS07225 1528655..1529524 + 870 WP_015366654.1 5'/3'-nucleotidase SurE -
EAG7_RS07230 1529778..1530257 + 480 Protein_1477 response regulator transcription factor -
EAG7_RS07235 1530353..1530850 + 498 WP_015366656.1 heme-binding protein -
EAG7_RS07240 1531251..1531784 + 534 WP_100280375.1 N-acetyltransferase -
EAG7_RS07245 1531839..1533074 - 1236 WP_015366658.1 MFS transporter -
EAG7_RS07250 1533347..1533613 + 267 WP_015366659.1 DUF1778 domain-containing protein Antitoxin
EAG7_RS07255 1533601..1534086 + 486 WP_032705770.1 GNAT family N-acetyltransferase Toxin
EAG7_RS07260 1534158..1535774 + 1617 WP_015366662.1 FAD-NAD(P)-binding protein -
EAG7_RS07265 1535893..1536993 + 1101 WP_015366663.1 NADH:flavin oxidoreductase/NADH oxidase -
EAG7_RS27245 1537050..1537208 - 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
EAG7_RS07270 1537469..1538539 + 1071 WP_015366664.1 mannonate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17573.23 Da        Isoelectric Point: 8.8793

>T54517 WP_032705770.1 NZ_CP011539:1533601-1534086 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHSEATGGLRRNM
PDPIPVIILARLAIDCAFHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T54517 NZ_CP011539:1533601-1534086 [Klebsiella aerogenes]
ATGGGAAAAATAAGCGCGCCTGCACCGCTATCTTCACACCATCAGATCGCGGAATTTTGTTGTGGAGAAACGGTTCTCGA
TCAATGGCTGAAACAGCGAGGATTGAAAAACCAGGCACAGGGCGCCGCGAGAACCTTTGTGGTCTGCAAGGAAGAGAGCC
ATCAGGTGGTGGGGTTTTATTCGTTAGCAACCGGCAGCGTTAATCACTCGGAAGCCACTGGCGGCCTGCGGCGCAATATG
CCCGATCCTATCCCGGTCATCATTCTCGCCCGCCTGGCGATCGACTGCGCGTTTCACGGACAGGGGCTGGGAGCTGATTT
ACTCCATGATGCGCTGTTACGCAGTTATCGCGTTGCCGAAAATGTTGGCGTACGTGCCCTGATGGTCCATGCCCTGACCG
ATAGCGCGAAACGATTCTATTTACACCACGGATTCAAAGCCTCAACCACCCAGGAACGCACTCTTTTCCTCGCGTTGCCT
AAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10075.52 Da        Isoelectric Point: 4.6558

>AT54517 WP_015366659.1 NZ_CP011539:1533347-1533613 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANSALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT54517 NZ_CP011539:1533347-1533613 [Klebsiella aerogenes]
ATGAAATCAGATATCCAACTCAACATCCGGGCGAAGGAGTCCCAGCGGGCGCTGATTGATGCGGCTGCCGAAATTCTGCA
CAAATCACGGACCGACTTTATTCTTGAGATGGCTTGCCAGGCGGCAGAAAACGTCATTCTCGACCGCCGGGTGTTTAACT
TAAGCGATGAGCAATACGCCGAATTTATCGACATGCTGGATGCGCCGGTTGAAGCTAACTCCGCTCTCGATAAATTGCTG
GCGAGAAAACCACAATGGGAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References