Detailed information of TA system TA054499

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1845481..1845967
• Replicon: chromosome
• Accession: NZ_CP011535
• Organism: Streptococcus pyogenes strain M28PF1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q48QR0
• Locus tag: ABO05_RS09080
• Protein ID: WP_014407961.1
• Coordinates: 1845481..1845750 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A660A1J7
• Locus tag: ABO05_RS09085
• Protein ID: WP_014407962.1
• Coordinates: 1845740..1845967 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABO05_RS09065	1840976..1842049	+	1074	WP_011285298.1	DUF4097 family beta strand repeat protein	-
ABO05_RS09070	1842166..1844439	-	2274	WP_021340697.1	YhgE/Pip domain-containing protein	-
ABO05_RS09075	1844574..1845107	+	534	WP_010922785.1	TetR/AcrR family transcriptional regulator	-
ABO05_RS09080	1845481..1845750	-	270	WP_014407961.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ABO05_RS09085	1845740..1845967	-	228	WP_014407962.1	hypothetical protein	Antitoxin
ABO05_RS09090	1846120..1846491	-	372	WP_011285302.1	DUF1492 domain-containing protein	-
ABO05_RS09095	1846481..1846828	-	348	WP_011285303.1	DUF1492 domain-containing protein	-
ABO05_RS09100	1847109..1847354	-	246	WP_011285304.1	hypothetical protein	-
ABO05_RS09105	1847329..1847604	-	276	WP_014407964.1	hypothetical protein	-
ABO05_RS09110	1847594..1847932	-	339	WP_030126557.1	replication protein	-
ABO05_RS09115	1847974..1848240	-	267	WP_011285307.1	hypothetical protein	-
ABO05_RS09120	1848237..1849025	-	789	WP_011285308.1	hypothetical protein	-
ABO05_RS10195	1849116..1849274	-	159	WP_011285309.1	hypothetical protein	-
ABO05_RS09125	1849288..1849533	-	246	WP_011285310.1	hypothetical protein	-
ABO05_RS09130	1849529..1849855	-	327	Protein_1757	hypothetical protein	-
ABO05_RS10200	1849857..1850030	-	174	WP_011285312.1	hypothetical protein	-
ABO05_RS09135	1850036..1850209	-	174	WP_000694580.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10497.50 Da
• Isoelectric Point: 10.5027

>T54499 WP_014407961.1 NZ_CP011535:c1845750-1845481 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Nucleotide

• Length: 270 bp

>T54499 NZ_CP011535:c1845750-1845481 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8641.63 Da
• Isoelectric Point: 3.9607

>AT54499 WP_014407962.1 NZ_CP011535:c1845967-1845740 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Nucleotide

• Length: 228 bp

>AT54499 NZ_CP011535:c1845967-1845740 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A660A202

Antitoxin

• AlphaFold DB: A0A660A1J7