Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1344860..1345776 Replicon chromosome
Accession NZ_CP011534
Organism Bacillus subtilis strain UD1022

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag ABA10_RS07045 Protein ID WP_047182497.1
Coordinates 1345030..1345776 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag ABA10_RS07040 Protein ID WP_003232646.1
Coordinates 1344860..1345030 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABA10_RS07005 1340578..1340907 + 330 WP_047182492.1 XkdW family protein -
ABA10_RS07010 1340904..1341068 + 165 WP_047182493.1 XkdX family protein -
ABA10_RS07015 1341112..1341951 + 840 WP_047182494.1 phage-like element PBSX protein XepA -
ABA10_RS07020 1342004..1342273 + 270 WP_003232655.1 hemolysin XhlA family protein -
ABA10_RS07025 1342285..1342548 + 264 WP_015483133.1 phage holin -
ABA10_RS07030 1342561..1343457 + 897 WP_047182495.1 N-acetylmuramoyl-L-alanine amidase -
ABA10_RS07035 1343534..1344625 + 1092 WP_047182496.1 acyltransferase family protein -
ABA10_RS21615 1344622..1344774 - 153 WP_131228329.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
ABA10_RS07040 1344860..1345030 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
ABA10_RS07045 1345030..1345776 - 747 WP_047182497.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
ABA10_RS07050 1345886..1346887 - 1002 WP_003232642.1 inorganic phosphate transporter -
ABA10_RS07055 1346900..1347517 - 618 WP_003218470.1 DUF47 domain-containing protein -
ABA10_RS07060 1347793..1349109 - 1317 WP_041850924.1 serine/threonine exchanger -
ABA10_RS07065 1349498..1350448 + 951 WP_047182498.1 ring-cleaving dioxygenase -
ABA10_RS21620 1350549..1350695 + 147 WP_019258173.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29043.47 Da        Isoelectric Point: 4.6191

>T54498 WP_047182497.1 NZ_CP011534:c1345776-1345030 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKISAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

>T54498 NZ_CP011534:c1345776-1345030 [Bacillus subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATCTCCGCCATCCGGAAAACTTGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATCGATGCTTTT
ATCTTCTTAAGTGCATACGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCTTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT54498 WP_003232646.1 NZ_CP011534:c1345030-1344860 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp

>AT54498 NZ_CP011534:c1345030-1344860 [Bacillus subtilis]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References