Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 807977..808454 Replicon chromosome
Accession NZ_CP011528
Organism Staphylococcus aureus strain RKI4

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag AA961_RS03915 Protein ID WP_000052076.1
Coordinates 807977..808165 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag AA961_RS03920 Protein ID WP_001059690.1
Coordinates 808194..808454 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA961_RS03885 804012..804488 + 477 WP_000824477.1 hypothetical protein -
AA961_RS03890 804829..805515 + 687 WP_001641381.1 thermonuclease family protein -
AA961_RS03895 805872..806072 + 201 WP_001059082.1 cold-shock protein -
AA961_RS03900 806568..806786 - 219 WP_000005887.1 hypothetical protein -
AA961_RS03905 806848..807132 - 285 WP_001004401.1 hypothetical protein -
AA961_RS03910 807220..807789 - 570 WP_001106652.1 hypothetical protein -
AA961_RS03915 807977..808165 - 189 WP_000052076.1 hypothetical protein Toxin
AA961_RS03920 808194..808454 - 261 WP_001059690.1 hypothetical protein Antitoxin
AA961_RS03925 808795..808998 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
AA961_RS03930 808995..809231 - 237 WP_000368687.1 hypothetical protein -
AA961_RS03935 809456..810037 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
AA961_RS03940 810110..810727 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
AA961_RS03945 810883..811377 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
AA961_RS03950 811776..812198 - 423 Protein_747 organic hydroperoxide resistance protein -
AA961_RS03955 812346..813062 + 717 WP_000150016.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T54477 WP_000052076.1 NZ_CP011528:c808165-807977 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T54477 NZ_CP011528:c808165-807977 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT54477 WP_001059690.1 NZ_CP011528:c808454-808194 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT54477 NZ_CP011528:c808454-808194 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References