54463

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 5184658..5185244 Replicon chromosome
Accession NZ_CP011525
Organism Pseudomonas sp. JY-Q

Toxin (Protein)


Gene name PumA Uniprot ID A0A2I0CCV1
Locus tag AA098_RS23310 Protein ID WP_004576348.1
Coordinates 5184951..5185244 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID I3UY28
Locus tag AA098_RS23305 Protein ID WP_004576347.1
Coordinates 5184658..5184954 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA098_RS23275 5180340..5180675 - 336 WP_003248556.1 preprotein translocase subunit YajC -
AA098_RS23280 5180718..5181833 - 1116 WP_003248558.1 tRNA guanosine(34) transglycosylase Tgt -
AA098_RS23285 5181848..5182897 - 1050 WP_004576301.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
AA098_RS23295 5183350..5183997 + 648 WP_064615263.1 serine protease -
AA098_RS23300 5184168..5184647 + 480 WP_004576346.1 GNAT family N-acetyltransferase -
AA098_RS23305 5184658..5184954 - 297 WP_004576347.1 putative addiction module antidote protein Antitoxin
AA098_RS23310 5184951..5185244 - 294 WP_004576348.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AA098_RS23315 5185468..5186361 + 894 WP_003248571.1 hypothetical protein -
AA098_RS23320 5186398..5187165 - 768 WP_004576349.1 phosphonate ABC transporter, permease protein PhnE -
AA098_RS23325 5187162..5187989 - 828 WP_003248575.1 ABC transporter permease subunit -
AA098_RS23330 5187983..5188792 - 810 WP_003248576.1 phosphonate ABC transporter ATP-binding protein -
AA098_RS23335 5188789..5189643 - 855 WP_064615033.1 putative selenate ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-96)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10751.55 Da        Isoelectric Point: 10.8302

>T54463 WP_004576348.1 NZ_CP011525:c5185244-5184951 [Pseudomonas sp. JY-Q]
MFLVEQTESFAAWLSSLRDLRARLAIGRRLERAAAGNLGDFKWLGGGIGELRIDVAAGYRVYFTQKGQRLVLLLVGGDKS
TQAADILNARKLLKEMK

Download         Length: 294 bp

>T54463 NZ_CP011525:c5185244-5184951 [Pseudomonas sp. JY-Q]
ATGTTTCTCGTTGAACAGACGGAAAGCTTTGCCGCTTGGCTATCGAGCTTGAGAGATTTGAGGGCCAGGCTGGCGATAGG
TCGTAGGCTGGAGCGAGCAGCGGCGGGCAATCTTGGTGACTTCAAGTGGCTTGGAGGCGGTATTGGTGAGCTTCGCATCG
ACGTAGCTGCCGGTTATCGCGTCTATTTCACGCAAAAGGGGCAGAGGTTGGTTTTACTGCTGGTCGGCGGCGACAAGTCC
ACCCAAGCCGCCGACATCCTCAACGCCAGAAAGCTGCTGAAGGAGATGAAATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10676.33 Da        Isoelectric Point: 6.7249

>AT54463 WP_004576347.1 NZ_CP011525:c5184954-5184658 [Pseudomonas sp. JY-Q]
MSEKLIPFDMAALLSSDEAISEYLSQVLSNGDTEEIIRALGHIARARGMTHIATESGLGRESLYKALSPGAKPRFDTVLR
VIRALGVDLLVQPHAMTR

Download         Length: 297 bp

>AT54463 NZ_CP011525:c5184954-5184658 [Pseudomonas sp. JY-Q]
ATGAGCGAAAAATTGATCCCGTTTGATATGGCAGCCTTGTTGAGCAGCGATGAGGCAATCAGTGAATACCTTAGCCAGGT
GCTATCAAATGGCGATACCGAGGAAATCATTCGAGCACTTGGCCATATCGCTCGTGCACGGGGCATGACACATATTGCTA
CGGAGAGTGGGCTGGGTAGAGAAAGCCTGTACAAGGCGCTGAGCCCTGGCGCGAAGCCTCGTTTTGACACTGTATTGAGG
GTCATTCGTGCTCTGGGGGTGGACCTTCTCGTTCAGCCACATGCAATGACCCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I0CCV1

Antitoxin

Source ID Structure
AlphaFold DB A0A2I0CD26

References