54461

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2410967..2411850 Replicon chromosome
Accession NZ_CP011525
Organism Pseudomonas sp. JY-Q

Toxin (Protein)


Gene name - Uniprot ID A0A173HDN1
Locus tag AA098_RS10955 Protein ID WP_019751987.1
Coordinates 2411413..2411850 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID I7C3Q7
Locus tag AA098_RS10950 Protein ID WP_003250525.1
Coordinates 2410967..2411416 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA098_RS10925 2406390..2407589 + 1200 WP_014861778.1 sugar transporter -
AA098_RS10930 2407629..2408213 - 585 WP_004573728.1 LysE family transporter -
AA098_RS10935 2408265..2409095 - 831 WP_003250518.1 AraC family transcriptional regulator -
AA098_RS10940 2409144..2410067 - 924 WP_064614214.1 LysR family transcriptional regulator -
AA098_RS10945 2410171..2410824 + 654 WP_064614215.1 oxygen-insensitive NAD(P)H nitroreductase -
AA098_RS10950 2410967..2411416 + 450 WP_003250525.1 DUF2384 domain-containing protein Antitoxin
AA098_RS10955 2411413..2411850 + 438 WP_019751987.1 RES family NAD+ phosphorylase Toxin
AA098_RS10960 2411908..2413062 - 1155 WP_060537721.1 aminotransferase class V-fold PLP-dependent enzyme -
AA098_RS10965 2413256..2414179 - 924 WP_004573723.1 LysR family transcriptional regulator -
AA098_RS10970 2414320..2415549 + 1230 WP_003250533.1 acyl-CoA dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-138)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(33-91)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15953.22 Da        Isoelectric Point: 6.0704

>T54461 WP_019751987.1 NZ_CP011525:2411413-2411850 [Pseudomonas sp. JY-Q]
VILWRISAYADLSGTGGLRVSGRWHQAGRPVVYAATSPPGAMLEVLVHLEIDPEDFPTTMRLLRIELPDTVSQAQLPALQ
PGWSAHPELTRTLGNRFLDDGSALLLPVPSAIMPSTTNYLFNPRHPQAQSAKIQVEDFTPDSRLF

Download         Length: 438 bp

>T54461 NZ_CP011525:2411413-2411850 [Pseudomonas sp. JY-Q]
GTGATTTTGTGGCGAATCAGCGCCTATGCAGACTTGAGTGGTACGGGGGGCTTGCGTGTAAGTGGCCGCTGGCACCAGGC
GGGGCGGCCGGTGGTGTATGCCGCCACCAGCCCTCCCGGGGCGATGCTGGAAGTGTTGGTGCACCTGGAGATCGACCCCG
AGGATTTCCCGACCACCATGCGCTTGCTTCGCATCGAACTGCCCGACACGGTTTCCCAGGCACAGTTGCCCGCTTTGCAG
CCCGGCTGGTCTGCTCACCCTGAGTTGACCCGTACGCTGGGCAATCGCTTTCTGGATGACGGTTCGGCATTGCTGCTGCC
GGTGCCAAGCGCGATCATGCCCAGCACCACCAATTACCTGTTCAACCCACGGCACCCGCAGGCGCAGAGCGCGAAAATCC
AGGTTGAGGATTTCACCCCGGACAGCCGCCTGTTCTAG

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16956.46 Da        Isoelectric Point: 5.7258

>AT54461 WP_003250525.1 NZ_CP011525:2410967-2411416 [Pseudomonas sp. JY-Q]
MLAEVLRDNGYHEYRARLQALLDIPELASDFEIHTRITDGFAATWLVKLTERGVLTPVERDQIIPLRTLKSRIERDQPLT
VDESDRLFRSAHITAMAEAVFGEAGKAKRWLSKPKERFSGLTPMQMLTTQQGTTQVEEMLLQIAEGYGL

Download         Length: 450 bp

>AT54461 NZ_CP011525:2410967-2411416 [Pseudomonas sp. JY-Q]
ATGCTTGCCGAAGTGCTTCGCGACAACGGTTACCACGAGTACCGGGCGCGCTTGCAGGCGCTGCTGGACATTCCCGAGCT
TGCCAGTGATTTCGAAATCCACACCCGCATCACCGATGGTTTTGCCGCCACCTGGTTGGTAAAGCTGACCGAACGCGGTG
TGCTCACGCCGGTGGAGCGCGACCAGATCATCCCGCTGCGCACCCTCAAATCCCGTATCGAGCGCGACCAACCGCTGACC
GTGGATGAGAGCGATCGGCTGTTCCGCTCGGCCCACATCACCGCCATGGCCGAGGCTGTGTTCGGTGAAGCGGGCAAGGC
CAAACGCTGGCTTTCCAAGCCCAAGGAGCGTTTCTCGGGGCTGACGCCGATGCAGATGCTCACCACCCAGCAAGGCACCA
CGCAGGTCGAAGAAATGCTGCTGCAGATTGCCGAGGGCTATGGCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A173HDN1

Antitoxin

Source ID Structure
AlphaFold DB I7C3Q7

References