Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RHH
Location 4010..4563 Replicon plasmid pPO70-3
Accession NZ_CP011520
Organism Pandoraea oxalativorans strain DSM 23570

Toxin (Protein)


Gene name relE Uniprot ID A0A0G3IGS5
Locus tag MB84_RS28115 Protein ID WP_052654794.1
Coordinates 4270..4563 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0G3IIY5
Locus tag MB84_RS28110 Protein ID WP_052654793.1
Coordinates 4010..4282 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MB84_RS28080 184..815 + 632 Protein_1 IS6 family transposase -
MB84_RS28085 844..1125 - 282 Protein_2 integrase core domain-containing protein -
MB84_RS28090 1142..2227 - 1086 WP_046289963.1 IS110 family transposase -
MB84_RS28095 2517..3382 - 866 Protein_4 IS3 family transposase -
MB84_RS29670 3481..3612 - 132 Protein_5 ATP-binding protein -
MB84_RS28105 3596..3844 - 249 Protein_6 recombinase family protein -
MB84_RS28110 4010..4282 + 273 WP_052654793.1 CopG family ribbon-helix-helix protein Antitoxin
MB84_RS28115 4270..4563 + 294 WP_052654794.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MB84_RS28120 4812..6062 + 1251 WP_046290551.1 IS256 family transposase -
MB84_RS28125 6203..7378 - 1176 WP_052654795.1 ATP-binding protein -
MB84_RS28130 7765..8994 + 1230 WP_052654796.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..75108 75108
- inside IScluster/Tn - - 844..6062 5218


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10670.22 Da        Isoelectric Point: 6.4615

>T54459 WP_052654794.1 NZ_CP011520:4270-4563 [Pandoraea oxalativorans]
VPQVIVTEGAAQGLERCRRFLAVKAPDAAKRAGQAIERQFLLLETAPDIGRPFPEMPELRELVIAFGDSGYVAAYRHEAA
ADAVYILAFRHQKDAGY

Download         Length: 294 bp

>T54459 NZ_CP011520:4270-4563 [Pandoraea oxalativorans]
GTGCCGCAAGTAATCGTCACCGAGGGTGCGGCGCAGGGCTTGGAGCGATGTCGCCGCTTCCTTGCCGTTAAGGCCCCAGA
TGCTGCCAAGCGCGCAGGTCAGGCCATCGAGCGGCAATTCCTGCTGCTGGAAACAGCTCCTGACATTGGTCGTCCATTCC
CCGAAATGCCGGAGCTGCGCGAACTTGTGATTGCCTTCGGCGATTCCGGCTATGTCGCCGCGTACCGCCACGAAGCGGCT
GCCGATGCGGTCTACATCCTAGCATTCCGACACCAGAAAGATGCGGGTTACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10594.87 Da        Isoelectric Point: 7.3596

>AT54459 WP_052654793.1 NZ_CP011520:4010-4282 [Pandoraea oxalativorans]
MATSLKIDDSLKGRVHQLATQRRRSPHWIMLEAIQQYVEREEARESFKQEALASWAAYQETGRHLTGQEVRTWLNTWGTE
HETTVPECRK

Download         Length: 273 bp

>AT54459 NZ_CP011520:4010-4282 [Pandoraea oxalativorans]
ATGGCAACATCGCTCAAAATCGACGATTCGCTGAAAGGTCGCGTCCACCAGCTCGCTACCCAGCGCCGTCGCTCACCCCA
CTGGATCATGCTGGAGGCCATCCAGCAGTACGTCGAGCGTGAGGAAGCCCGCGAGAGCTTCAAGCAGGAAGCCTTGGCAT
CGTGGGCGGCTTATCAGGAAACCGGTCGGCACCTGACAGGCCAAGAGGTTCGCACCTGGTTAAACACCTGGGGCACGGAA
CATGAAACGACGGTGCCTGAGTGCCGCAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3IGS5

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3IIY5

References