Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 570862..571469 Replicon plasmid pPO70-1
Accession NZ_CP011518
Organism Pandoraea oxalativorans strain DSM 23570

Toxin (Protein)


Gene name vapC Uniprot ID A0A0G3IBR4
Locus tag MB84_RS27190 Protein ID WP_052654150.1
Coordinates 570862..571275 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0G3IEE1
Locus tag MB84_RS27195 Protein ID WP_052654621.1
Coordinates 571272..571469 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MB84_RS27165 566254..566631 + 378 WP_157123083.1 hypothetical protein -
MB84_RS27170 566825..567898 + 1074 WP_157123085.1 hypothetical protein -
MB84_RS27175 568335..569531 + 1197 WP_052654141.1 hypothetical protein -
MB84_RS27180 569846..570103 - 258 WP_169835094.1 transposase domain-containing protein -
MB84_RS29585 570125..570526 - 402 WP_169835095.1 transposase -
MB84_RS29590 570487..570681 - 195 Protein_456 transposase -
MB84_RS27190 570862..571275 - 414 WP_052654150.1 type II toxin-antitoxin system VapC family toxin Toxin
MB84_RS27195 571272..571469 - 198 WP_052654621.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MB84_RS30350 572365..573627 + 1263 WP_157123087.1 hypothetical protein -
MB84_RS27205 573632..573862 - 231 WP_052654156.1 DUF2274 domain-containing protein -
MB84_RS27215 573972..575139 + 1168 Protein_461 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..633357 633357


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-46)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14809.26 Da        Isoelectric Point: 8.1148

>T54458 WP_052654150.1 NZ_CP011518:c571275-570862 [Pandoraea oxalativorans]
MILVDTSVWIDHLRAGDAALVRLLETGRVLVHPYVIGELALGSLKNRELVISTLGDLPRVTVATHEEVQRFVGEQTLFGC
GIGYVDVHLLAATRLTPGAALWTRDTRLAATAARLSLAANILHQAVRWPAIRGISGL

Download         Length: 414 bp

>T54458 NZ_CP011518:c571275-570862 [Pandoraea oxalativorans]
ATGATTCTGGTCGACACGTCAGTGTGGATTGATCACTTGCGCGCGGGTGATGCGGCACTCGTCCGGTTGCTTGAGACCGG
ACGAGTGCTGGTGCATCCGTACGTCATCGGTGAACTTGCTCTCGGAAGCTTGAAGAACCGTGAGCTTGTGATTTCAACGC
TGGGGGATCTGCCTCGCGTGACCGTGGCCACGCACGAAGAGGTGCAGCGCTTCGTGGGTGAGCAAACCCTCTTTGGATGC
GGGATTGGCTACGTGGACGTGCATCTGCTGGCCGCGACGCGTTTAACGCCGGGGGCGGCTTTATGGACCAGAGACACGCG
TCTGGCCGCGACAGCGGCGCGGCTTTCGTTGGCGGCCAACATCCTGCATCAGGCTGTGCGTTGGCCTGCTATTCGTGGAA
TCAGTGGTCTTTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7132.17 Da        Isoelectric Point: 8.8949

>AT54458 WP_052654621.1 NZ_CP011518:c571469-571272 [Pandoraea oxalativorans]
MRTTLALDDDLLAKAQAFTGLQEKSALIREALKALIERESARRLARLGGTEADLGDIPRRQTQPA

Download         Length: 198 bp

>AT54458 NZ_CP011518:c571469-571272 [Pandoraea oxalativorans]
ATGCGGACGACTTTGGCGCTTGATGATGATCTTTTGGCGAAGGCTCAAGCCTTCACCGGCTTGCAGGAAAAATCGGCGCT
GATCCGCGAGGCACTCAAGGCGTTGATCGAGCGTGAAAGCGCCCGCCGCTTGGCGCGTTTGGGGGGAACCGAGGCTGACC
TTGGTGACATTCCTCGACGCCAAACGCAGCCTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3IBR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3IEE1

References