Detailed information of TA system TA054457

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3488672..3489335
• Replicon: chromosome
• Accession: NZ_CP011516
• Organism: Edwardsiella sp. LADL05-105

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: AAZ33_RS15525
• Protein ID: WP_034164690.1
• Coordinates: 3488672..3489088 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D0ZDY6
• Locus tag: AAZ33_RS15530
• Protein ID: WP_012849755.1
• Coordinates: 3489069..3489335 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AAZ33_RS15505	3484602..3486335	-	1734	WP_034164685.1	single-stranded-DNA-specific exonuclease RecJ	-
AAZ33_RS15510	3486340..3487056	-	717	WP_034164686.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
AAZ33_RS15515	3487084..3487983	-	900	WP_034164688.1	site-specific tyrosine recombinase XerD	-
AAZ33_RS15520	3488135..3488647	+	513	WP_034164689.1	flavodoxin FldB	-
AAZ33_RS15525	3488672..3489088	-	417	WP_034164690.1	protein YgfX	Toxin
AAZ33_RS15530	3489069..3489335	-	267	WP_012849755.1	FAD assembly factor SdhE	Antitoxin
AAZ33_RS15535	3489684..3490682	+	999	WP_034164692.1	tRNA-modifying protein YgfZ	-
AAZ33_RS15540	3490724..3491548	-	825	WP_034164693.1	shikimate 5-dehydrogenase	-
AAZ33_RS15545	3491705..3492577	-	873	WP_034164695.1	nucleoside-specific channel-forming protein Tsx	-
AAZ33_RS15550	3493186..3493836	+	651	WP_034164746.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16229.03 Da
• Isoelectric Point: 11.6049

>T54457 WP_034164690.1 NZ_CP011516:c3489088-3488672 [Edwardsiella sp. LADL05-105]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSAFWLVLLVAVIFECIRSQRRIARNRGELQLLTPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGVPCRRRLWLAADSMSREEWGQLRRALLDTGDDRA

Nucleotide

• Length: 417 bp

>T54457 NZ_CP011516:c3489088-3488672 [Edwardsiella sp. LADL05-105]
GTGGTCCTTTGGCGCTGTAACGTTCACGTCTCCTGGCGTACCCAGGTGATGTTTCTGCTGGGGCACGGCGCGCTGGTTTT
GGCGATCCTGCTGGCGCCCTGGCCGGAAAACTACAGCGCATTCTGGCTGGTTCTGCTGGTGGCGGTGATCTTTGAGTGTA
TCCGCAGCCAGCGTCGGATTGCGCGTAACCGCGGTGAGCTGCAGCTGCTGACGCCGCAGGTGTGGCACTGGCAGCTGCGC
GAGTGGCGCCTGGCCCGGCGCCCCTGGGTTAGCGATCTGGGGGCGCTGCTGATTCTGCAGAGTACCCATGGTGTACCGTG
CCGCCGCCGTCTGTGGCTGGCGGCCGACAGCATGAGCCGAGAAGAGTGGGGGCAGCTGCGCCGCGCGCTGCTCGATACGG
GCGACGATCGCGCATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10318.90 Da
• Isoelectric Point: 5.6951

>AT54457 WP_012849755.1 NZ_CP011516:c3489335-3489069 [Edwardsiella sp. LADL05-105]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT54457 NZ_CP011516:c3489335-3489069 [Edwardsiella sp. LADL05-105]
ATGGATATCAATAATAAAGCGCGGGTTCACTGGGCGTGCCGCCGCGGAATGCGCGAGCTGGATATCGCGATTATGCCTTT
CTTTGAACATGAGTATGATGCGCTTAACGATGCCGATAAACAGACCTTTGTCCGCCTGCTGGCCTGCGACGATCCTGAGC
TATTTAAATGGCTGATGAACCAGGGTAAGCCGGACGACGCTGATCTGGCCCGTATGATTACGCTGATTCAGACGCGAAAT
AAAGAACGTGGTCCTTTGGCGCTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A034T2Q8