Detailed information of TA system TA054448

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1856350..1856872
• Replicon: chromosome
• Accession: NZ_CP011516
• Organism: Edwardsiella sp. LADL05-105

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5BBL4
• Locus tag: AAZ33_RS08395
• Protein ID: WP_015871319.1
• Coordinates: 1856350..1856631 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5BBL3
• Locus tag: AAZ33_RS08400
• Protein ID: WP_015871318.1
• Coordinates: 1856621..1856872 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AAZ33_RS08380	1851764..1852539	+	776	Protein_1656	hypothetical protein	-
AAZ33_RS08385	1852532..1854193	+	1662	WP_049703944.1	terminase	-
AAZ33_RS08390	1854190..1856278	+	2089	Protein_1658	portal protein	-
AAZ33_RS08395	1856350..1856631	-	282	WP_015871319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AAZ33_RS08400	1856621..1856872	-	252	WP_015871318.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
AAZ33_RS08405	1857160..1857627	+	468	Protein_1661	hypothetical protein	-
AAZ33_RS08410	1857638..1857985	+	348	WP_144242832.1	hypothetical protein	-
AAZ33_RS08415	1858357..1860231	+	1875	WP_034165826.1	PhoX family phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1823723..1866839	43116

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10783.62 Da
• Isoelectric Point: 10.6993

>T54448 WP_015871319.1 NZ_CP011516:c1856631-1856350 [Edwardsiella sp. LADL05-105]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Nucleotide

• Length: 282 bp

>T54448 NZ_CP011516:c1856631-1856350 [Edwardsiella sp. LADL05-105]
ATGACCTATAAACTGAGCTTTGAAAAGCGAGCCCTGAAAGAGTGGAAAAAACTGGCGCCGCCGATTCAAAGCCAGTTGAA
AAAGAAACTGATCGAACGCCTGGAAAACCCACATGTTCCAGCAGCACGCTTAAGTGGGCGCGCTAACCGTTATAAAATAA
AATTACGCTCTTCCGGTTACCGGTTAGTTTATGAAGTCAACGATAGCGAAATTATCCTGCTGGTGATCGCGATCGGTAAA
CGGGCCGATAACGAGGTGTACCAAGCGGCAGACAGTCGTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9155.24 Da
• Isoelectric Point: 3.7550

>AT54448 WP_015871318.1 NZ_CP011516:c1856872-1856621 [Edwardsiella sp. LADL05-105]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT54448 NZ_CP011516:c1856872-1856621 [Edwardsiella sp. LADL05-105]
ATGGCATACCAAATTCTCACGACCACCGCCGCCAGCATTACCGACCTGAAACGCAATCCAATGGGTACCATTGCTGAAGG
TGACGGCAATGCCGTAGCAATCTTAAACCGCAATGAGCCGGCCTTTTACTGCGTTCCACCGGAACTCTACGCTTACTATC
TGGAGCTGGCTGAAGATGCGGCACTTAATCGTATCGCCGATGAGCGTCTGGAGGACGCTGAGTTTGTCAGCGTAAATATC
GATGACCTATAA

Structures

Toxin

• AlphaFold DB: C5BBL4

Antitoxin

• AlphaFold DB: C5BBL3