Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1168312..1168904 Replicon chromosome
Accession NZ_CP011516
Organism Edwardsiella sp. LADL05-105

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag AAZ33_RS05290 Protein ID WP_012847872.1
Coordinates 1168312..1168515 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A034T4H2
Locus tag AAZ33_RS05295 Protein ID WP_034163649.1
Coordinates 1168536..1168904 (-) Length 123 a.a.

Genomic Context

AAZ33_RS05265AAZ33_RS05270AAZ33_RS05275AAZ33_RS05280AAZ33_RS05285AAZ33_RS05290AAZ33_RS05295AAZ33_RS05300AAZ33_RS05305
Location: 1164144..1164605 (462 bp)
Type: Others
Protein ID: WP_034163655.1
Location: 1164865..1165203 (339 bp)
Type: Others
Protein ID: WP_034163654.1
Location: 1165224..1166489 (1266 bp)
Type: Others
Protein ID: WP_049703936.1
Location: 1166524..1167390 (867 bp)
Type: Others
Protein ID: WP_034163652.1
Location: 1167496..1167825 (330 bp)
Type: Others
Protein ID: WP_034163651.1
Location: 1168312..1168515 (204 bp)
Type: Toxin
Protein ID: WP_012847872.1
Location: 1168536..1168904 (369 bp)
Type: Antitoxin
Protein ID: WP_034163649.1
Location: 1169271..1172423 (3153 bp)
Type: Others
Protein ID: WP_034163648.1
Location: 1172467..1173651 (1185 bp)
Type: Others
Protein ID: WP_034163646.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AAZ33_RS052651164144..1164605+462WP_034163655.1Lrp/AsnC family transcriptional regulator-
AAZ33_RS052701164865..1165203+339WP_034163654.1P-II family nitrogen regulator-
AAZ33_RS052751165224..1166489+1266WP_049703936.1ammonium transporter AmtB-
AAZ33_RS052801166524..1167390-867WP_034163652.1acyl-CoA thioesterase II-
AAZ33_RS052851167496..1167825-330WP_034163651.1MGMT family protein-
AAZ33_RS052901168312..1168515-204WP_012847872.1hemolysin expression modulator HhaToxin
AAZ33_RS052951168536..1168904-369WP_034163649.1Hha toxicity modulator TomBAntitoxin
AAZ33_RS053001169271..1172423-3153WP_034163648.1multidrug efflux RND transporter permease subunit-
AAZ33_RS053051172467..1173651-1185WP_034163646.1efflux RND transporter periplasmic adaptor subunit-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T54447 WP_012847872.1 NZ_CP011516:c1168515-1168312 [Edwardsiella sp. LADL05-105]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T54447 NZ_CP011516:c1168515-1168312 [Edwardsiella sp. LADL05-105]
ATGACCAAGATCGATTATCTAATGAAGCTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAACTAGAAATTTTTTATTCTGCTGCAGATCATCGACTAGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCGGCAGAAGTCTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14118.85 Da        Isoelectric Point: 6.2108

>AT54447 WP_034163649.1 NZ_CP011516:c1168904-1168536 [Edwardsiella sp. LADL05-105]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPRHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT54447 NZ_CP011516:c1168904-1168536 [Edwardsiella sp. LADL05-105]
ATGGATGAGTATACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAACCTACAGCTTAACGAGCTGATTGAGC
ATATTGCCAGCGTCGCACAATCATTTAAGATCAAATATCCGCGTCATTCGGATTTAGCCGAAATACTGGATGATTATCTG
GATGAAACCTACGCCCTGTTTGGTGCCTATAGCGTCAGTGAAACGGCGCTCAGACACTGGCTGCGTACCAAACGCCGTGT
GGCATACTGCCTGGCGCATGAAAAGCGCAATGCGGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A034SMG4

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A034T4H2

References