Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1168312..1168904 Replicon chromosome
Accession NZ_CP011516
Organism Edwardsiella sp. LADL05-105

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag AAZ33_RS05290 Protein ID WP_012847872.1
Coordinates 1168312..1168515 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A034T4H2
Locus tag AAZ33_RS05295 Protein ID WP_034163649.1
Coordinates 1168536..1168904 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AAZ33_RS05265 1164144..1164605 + 462 WP_034163655.1 Lrp/AsnC family transcriptional regulator -
AAZ33_RS05270 1164865..1165203 + 339 WP_034163654.1 P-II family nitrogen regulator -
AAZ33_RS05275 1165224..1166489 + 1266 WP_049703936.1 ammonium transporter AmtB -
AAZ33_RS05280 1166524..1167390 - 867 WP_034163652.1 acyl-CoA thioesterase II -
AAZ33_RS05285 1167496..1167825 - 330 WP_034163651.1 MGMT family protein -
AAZ33_RS05290 1168312..1168515 - 204 WP_012847872.1 hemolysin expression modulator Hha Toxin
AAZ33_RS05295 1168536..1168904 - 369 WP_034163649.1 Hha toxicity modulator TomB Antitoxin
AAZ33_RS05300 1169271..1172423 - 3153 WP_034163648.1 multidrug efflux RND transporter permease subunit -
AAZ33_RS05305 1172467..1173651 - 1185 WP_034163646.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T54447 WP_012847872.1 NZ_CP011516:c1168515-1168312 [Edwardsiella sp. LADL05-105]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T54447 NZ_CP011516:c1168515-1168312 [Edwardsiella sp. LADL05-105]
ATGACCAAGATCGATTATCTAATGAAGCTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAACTAGAAATTTTTTATTCTGCTGCAGATCATCGACTAGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCGGCAGAAGTCTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14118.85 Da        Isoelectric Point: 6.2108

>AT54447 WP_034163649.1 NZ_CP011516:c1168904-1168536 [Edwardsiella sp. LADL05-105]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPRHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT54447 NZ_CP011516:c1168904-1168536 [Edwardsiella sp. LADL05-105]
ATGGATGAGTATACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAACCTACAGCTTAACGAGCTGATTGAGC
ATATTGCCAGCGTCGCACAATCATTTAAGATCAAATATCCGCGTCATTCGGATTTAGCCGAAATACTGGATGATTATCTG
GATGAAACCTACGCCCTGTTTGGTGCCTATAGCGTCAGTGAAACGGCGCTCAGACACTGGCTGCGTACCAAACGCCGTGT
GGCATACTGCCTGGCGCATGAAAAGCGCAATGCGGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB A0A034T4H2

References