Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3518955..3519586 Replicon chromosome
Accession NZ_CP011511
Organism Shigella boydii strain ATCC 9210

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag ABE81_RS19395 Protein ID WP_001259385.1
Coordinates 3519311..3519586 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag ABE81_RS19390 Protein ID WP_000593554.1
Coordinates 3518955..3519314 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABE81_RS19365 3515087..3516031 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
ABE81_RS19370 3516028..3516861 + 834 WP_001008950.1 nickel ABC transporter permease subunit NikC -
ABE81_RS19375 3516861..3517625 + 765 WP_001136224.1 nickel import ATP-binding protein NikD -
ABE81_RS19380 3517622..3518428 + 807 WP_000173706.1 nickel import ATP-binding protein NikE -
ABE81_RS19385 3518434..3518835 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
ABE81_RS19390 3518955..3519314 - 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ABE81_RS19395 3519311..3519586 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
ABE81_RS19400 3519659..3520783 - 1125 WP_001216257.1 ABC transporter permease -
ABE81_RS19405 3520783..3523518 - 2736 WP_000149139.1 ribosome-associated ATPase/putative transporter RbbA -
ABE81_RS19410 3523515..3524582 - 1068 WP_000361467.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T54444 WP_001259385.1 NZ_CP011511:c3519586-3519311 [Shigella boydii]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T54444 NZ_CP011511:c3519586-3519311 [Shigella boydii]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT54444 WP_000593554.1 NZ_CP011511:c3519314-3518955 [Shigella boydii]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT54444 NZ_CP011511:c3519314-3518955 [Shigella boydii]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCTAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References