Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3144521..3145175 Replicon chromosome
Accession NZ_CP011511
Organism Shigella boydii strain ATCC 9210

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag ABE81_RS17345 Protein ID WP_000244777.1
Coordinates 3144768..3145175 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag ABE81_RS17340 Protein ID WP_000354046.1
Coordinates 3144521..3144787 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABE81_RS17315 3139690..3140433 + 744 Protein_3130 SDR family oxidoreductase -
ABE81_RS17320 3140490..3141923 - 1434 WP_004986559.1 6-phospho-beta-glucosidase BglA -
ABE81_RS17325 3141968..3142279 + 312 WP_001182983.1 N(4)-acetylcytidine aminohydrolase -
ABE81_RS17330 3142443..3143102 + 660 WP_000250272.1 hemolysin III family protein -
ABE81_RS17335 3143298..3144278 - 981 WP_000886094.1 tRNA-modifying protein YgfZ -
ABE81_RS17340 3144521..3144787 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
ABE81_RS17345 3144768..3145175 + 408 WP_000244777.1 toxin CptA Toxin
ABE81_RS17350 3145215..3145736 - 522 WP_001055874.1 flavodoxin FldB -
ABE81_RS17355 3145848..3146744 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
ABE81_RS17360 3146769..3147479 + 711 WP_000715205.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ABE81_RS17365 3147485..3149218 + 1734 WP_000813210.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T54443 WP_000244777.1 NZ_CP011511:3144768-3145175 [Shigella boydii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T54443 NZ_CP011511:3144768-3145175 [Shigella boydii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGATTGTTGATGGACGGACGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT54443 WP_000354046.1 NZ_CP011511:3144521-3144787 [Shigella boydii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT54443 NZ_CP011511:3144521-3144787 [Shigella boydii]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References