Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3980447..3980976 Replicon chromosome
Accession NZ_CP011510
Organism Mycobacterium tuberculosis strain Beijing

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag TM57_RS18650 Protein ID WP_003417760.1
Coordinates 3980447..3980704 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag TM57_RS18655 Protein ID WP_003417757.1
Coordinates 3980701..3980976 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TM57_RS18620 3976875..3977267 + 393 WP_003417776.1 roadblock/LC7 domain-containing protein -
TM57_RS18625 3977245..3977613 + 369 WP_003417772.1 DUF742 domain-containing protein -
TM57_RS18630 3977594..3978175 + 582 WP_003417769.1 ATP/GTP-binding protein -
TM57_RS18635 3978182..3978733 + 552 WP_003417767.1 pentapeptide repeat protein MfpA -
TM57_RS18640 3978730..3979098 - 369 WP_003417765.1 FHA domain-containing protein -
TM57_RS18645 3979215..3980405 - 1191 WP_003900033.1 NADH:flavin oxidoreductase -
TM57_RS18650 3980447..3980704 - 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
TM57_RS18655 3980701..3980976 - 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
TM57_RS18660 3981100..3981945 + 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
TM57_RS18665 3981942..3982235 + 294 WP_003417749.1 DUF3017 domain-containing protein -
TM57_RS18670 3982249..3982638 - 390 WP_003417745.1 DUF732 domain-containing protein -
TM57_RS22345 3982741..3984178 + 1438 Protein_3666 FAD-binding oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T54428 WP_003417760.1 NZ_CP011510:c3980704-3980447 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T54428 NZ_CP011510:c3980704-3980447 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT54428 WP_003417757.1 NZ_CP011510:c3980976-3980701 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT54428 NZ_CP011510:c3980976-3980701 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References