54424

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 2975472..2975998 Replicon chromosome
Accession NZ_CP011510
Organism Mycobacterium tuberculosis strain Beijing

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag TM57_RS14145 Protein ID WP_003401560.1
Coordinates 2975472..2975774 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID P9WJ08
Locus tag TM57_RS14150 Protein ID WP_003401555.1
Coordinates 2975771..2975998 (-) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TM57_RS14125 2973108..2974016 - 909 WP_003900117.1 SDR family NAD(P)-dependent oxidoreductase -
TM57_RS14130 2974013..2974645 - 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
TM57_RS14135 2974781..2975206 - 426 WP_003401566.1 PIN domain nuclease -
TM57_RS14140 2975203..2975424 - 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 -
TM57_RS14145 2975472..2975774 - 303 WP_003401560.1 toxin-antitoxin system toxin Toxin
TM57_RS14150 2975771..2975998 - 228 WP_003401555.1 ribbon-helix-helix protein, CopG family Antitoxin
TM57_RS14155 2976141..2977916 - 1776 WP_010886074.1 PE family protein -
TM57_RS14160 2978095..2979492 + 1398 WP_003401544.1 sulfatase -
TM57_RS14165 2979502..2980305 + 804 WP_003401540.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(6-41)


Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T54424 WP_003401560.1 NZ_CP011510:c2975774-2975472 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

>T54424 NZ_CP011510:c2975774-2975472 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8130.21 Da        Isoelectric Point: 7.0084

>AT54424 WP_003401555.1 NZ_CP011510:c2975998-2975771 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Download         Length: 228 bp

>AT54424 NZ_CP011510:c2975998-2975771 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGAGCGGCCGGAAGTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4F8T1

References