Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2636990..2637633 Replicon chromosome
Accession NZ_CP011510
Organism Mycobacterium tuberculosis strain Beijing

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag TM57_RS12565 Protein ID WP_003403187.1
Coordinates 2636990..2637391 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag TM57_RS12570 Protein ID WP_003403184.1
Coordinates 2637388..2637633 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TM57_RS12540 2633948..2634553 - 606 WP_003898526.1 hypothetical protein -
TM57_RS12545 2634695..2634916 + 222 WP_003898525.1 DUF4926 domain-containing protein -
TM57_RS12550 2634968..2636125 + 1158 WP_003898524.1 hypothetical protein -
TM57_RS21900 2636205..2636402 + 198 WP_003403191.1 hypothetical protein -
TM57_RS21905 2636435..2636602 + 168 WP_077385191.1 DUF3800 domain-containing protein -
TM57_RS12565 2636990..2637391 - 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
TM57_RS12570 2637388..2637633 - 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
TM57_RS12575 2637678..2638148 - 471 WP_003898523.1 hypothetical protein -
TM57_RS12580 2638151..2638861 - 711 Protein_2456 transposase -
TM57_RS12585 2638863..2639447 - 585 WP_003403171.1 IS607-like element IS1536 family transposase -
TM57_RS12590 2639688..2640638 - 951 WP_003900184.1 DUF1259 domain-containing protein -
TM57_RS12595 2640710..2641021 - 312 WP_003403164.1 hypothetical protein -
TM57_RS12600 2641078..2641839 + 762 WP_003403148.1 two-component system response regulator TcrA -
TM57_RS12605 2641823..2642353 + 531 WP_003917320.1 two component system sensor kinase HK2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T54416 WP_003403187.1 NZ_CP011510:c2637391-2636990 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T54416 NZ_CP011510:c2637391-2636990 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT54416 WP_003403184.1 NZ_CP011510:c2637633-2637388 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT54416 NZ_CP011510:c2637633-2637388 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References