Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2629470..2630095 Replicon chromosome
Accession NZ_CP011510
Organism Mycobacterium tuberculosis strain Beijing

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag TM57_RS12510 Protein ID WP_003403218.1
Coordinates 2629470..2629871 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag TM57_RS12515 Protein ID WP_003403213.1
Coordinates 2629868..2630095 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TM57_RS12485 2624560..2625507 - 948 WP_003403232.1 DUF732 domain-containing protein -
TM57_RS12490 2625611..2626675 - 1065 WP_003898532.1 hypothetical protein -
TM57_RS12500 2627070..2628161 - 1092 WP_003900977.1 galactokinase -
TM57_RS21295 2628158..2628649 - 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
TM57_RS21300 2628646..2629341 - 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
TM57_RS12510 2629470..2629871 - 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
TM57_RS12515 2629868..2630095 - 228 WP_003403213.1 antitoxin VapB29 Antitoxin
TM57_RS12525 2630290..2630532 - 243 WP_003403210.1 hypothetical protein -
TM57_RS12530 2630529..2631278 - 750 WP_003898528.1 hypothetical protein -
TM57_RS12535 2631362..2633929 + 2568 WP_003901879.1 SEC-C domain-containing protein -
TM57_RS12540 2633948..2634553 - 606 WP_003898526.1 hypothetical protein -
TM57_RS12545 2634695..2634916 + 222 WP_003898525.1 DUF4926 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T54415 WP_003403218.1 NZ_CP011510:c2629871-2629470 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T54415 NZ_CP011510:c2629871-2629470 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT54415 WP_003403213.1 NZ_CP011510:c2630095-2629868 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT54415 NZ_CP011510:c2630095-2629868 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References