Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2623818..2624467 Replicon chromosome
Accession NZ_CP011510
Organism Mycobacterium tuberculosis strain Beijing

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag TM57_RS12475 Protein ID WP_003403236.1
Coordinates 2623818..2624213 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag TM57_RS12480 Protein ID WP_003403235.1
Coordinates 2624213..2624467 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TM57_RS12450 2619145..2620872 + 1728 WP_003901883.1 exodeoxyribonuclease V subunit alpha -
TM57_RS12455 2620965..2622116 + 1152 WP_003403248.1 FIST C-terminal domain-containing protein -
TM57_RS12460 2622188..2622595 - 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
TM57_RS12465 2622592..2622852 - 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
TM57_RS12470 2622984..2623724 + 741 WP_003403239.1 TVP38/TMEM64 family protein -
TM57_RS12475 2623818..2624213 - 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
TM57_RS12480 2624213..2624467 - 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
TM57_RS12485 2624560..2625507 - 948 WP_003403232.1 DUF732 domain-containing protein -
TM57_RS12490 2625611..2626675 - 1065 WP_003898532.1 hypothetical protein -
TM57_RS12500 2627070..2628161 - 1092 WP_003900977.1 galactokinase -
TM57_RS21295 2628158..2628649 - 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
TM57_RS21300 2628646..2629341 - 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T54414 WP_003403236.1 NZ_CP011510:c2624213-2623818 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T54414 NZ_CP011510:c2624213-2623818 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT54414 WP_003403235.1 NZ_CP011510:c2624467-2624213 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT54414 NZ_CP011510:c2624467-2624213 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References