Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2586727..2587360 Replicon chromosome
Accession NZ_CP011510
Organism Mycobacterium tuberculosis strain Beijing

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag TM57_RS12290 Protein ID WP_003403365.1
Coordinates 2586977..2587360 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag TM57_RS12285 Protein ID WP_003403368.1
Coordinates 2586727..2586882 (+) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TM57_RS12255 2581844..2584207 - 2364 WP_003901895.1 arylsulfatase AtsD -
TM57_RS12260 2584321..2584575 + 255 WP_003911263.1 antitoxin VapB7 -
TM57_RS12265 2584572..2585009 + 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
TM57_RS12270 2585119..2585364 + 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
TM57_RS12275 2585351..2585659 + 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
TM57_RS12280 2585935..2586651 + 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
TM57_RS12285 2586727..2586882 + 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
TM57_RS12290 2586977..2587360 + 384 WP_003403365.1 ribonuclease VapC6 Toxin
TM57_RS12295 2587748..2588758 - 1011 WP_003911248.1 ABC transporter ATP-binding protein -
TM57_RS12300 2588839..2590344 - 1506 WP_003403360.1 carotenoid cleavage oxygenase -
TM57_RS12305 2590415..2591110 + 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
TM57_RS12310 2591103..2591495 - 393 WP_003403353.1 50S ribosomal protein L7/L12 -
TM57_RS12315 2591532..2592068 - 537 WP_003403341.1 50S ribosomal protein L10 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T54412 WP_003403365.1 NZ_CP011510:2586977-2587360 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T54412 NZ_CP011510:2586977-2587360 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT54412 WP_003403368.1 NZ_CP011510:2586727-2586882 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT54412 NZ_CP011510:2586727-2586882 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References