Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VapB |
Location | 2586727..2587360 | Replicon | chromosome |
Accession | NZ_CP011510 | ||
Organism | Mycobacterium tuberculosis strain Beijing |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TQD6 |
Locus tag | TM57_RS12290 | Protein ID | WP_003403365.1 |
Coordinates | 2586977..2587360 (+) | Length | 128 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P9WJ56 |
Locus tag | TM57_RS12285 | Protein ID | WP_003403368.1 |
Coordinates | 2586727..2586882 (+) | Length | 52 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
TM57_RS12255 | 2581844..2584207 | - | 2364 | WP_003901895.1 | arylsulfatase AtsD | - |
TM57_RS12260 | 2584321..2584575 | + | 255 | WP_003911263.1 | antitoxin VapB7 | - |
TM57_RS12265 | 2584572..2585009 | + | 438 | WP_003403386.1 | type II toxin-antitoxin system VapC family toxin | - |
TM57_RS12270 | 2585119..2585364 | + | 246 | WP_003403381.1 | ribbon-helix-helix protein, CopG family | - |
TM57_RS12275 | 2585351..2585659 | + | 309 | WP_003403376.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
TM57_RS12280 | 2585935..2586651 | + | 717 | WP_003403371.1 | CPBP family intramembrane metalloprotease | - |
TM57_RS12285 | 2586727..2586882 | + | 156 | WP_003403368.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
TM57_RS12290 | 2586977..2587360 | + | 384 | WP_003403365.1 | ribonuclease VapC6 | Toxin |
TM57_RS12295 | 2587748..2588758 | - | 1011 | WP_003911248.1 | ABC transporter ATP-binding protein | - |
TM57_RS12300 | 2588839..2590344 | - | 1506 | WP_003403360.1 | carotenoid cleavage oxygenase | - |
TM57_RS12305 | 2590415..2591110 | + | 696 | WP_003403355.1 | TetR/AcrR family transcriptional regulator | - |
TM57_RS12310 | 2591103..2591495 | - | 393 | WP_003403353.1 | 50S ribosomal protein L7/L12 | - |
TM57_RS12315 | 2591532..2592068 | - | 537 | WP_003403341.1 | 50S ribosomal protein L10 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 13959.73 Da Isoelectric Point: 6.0803
>T54412 WP_003403365.1 NZ_CP011510:2586977-2587360 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD
Download Length: 384 bp
>T54412 NZ_CP011510:2586977-2587360 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG
Antitoxin
Download Length: 52 a.a. Molecular weight: 5872.72 Da Isoelectric Point: 5.7734
>AT54412 WP_003403368.1 NZ_CP011510:2586727-2586882 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE
Download Length: 156 bp
>AT54412 NZ_CP011510:2586727-2586882 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQD6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BSF8 |