Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 2584572..2585364 Replicon chromosome
Accession NZ_CP011510
Organism Mycobacterium tuberculosis strain Beijing

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag TM57_RS12265 Protein ID WP_003403386.1
Coordinates 2584572..2585009 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag TM57_RS12270 Protein ID WP_003403381.1
Coordinates 2585119..2585364 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TM57_RS12240 2581035..2581208 - 174 WP_003898549.1 hypothetical protein -
TM57_RS12245 2581205..2581543 - 339 WP_003403405.1 PIN domain-containing protein -
TM57_RS12250 2581455..2581781 - 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
TM57_RS12255 2581844..2584207 - 2364 WP_003901895.1 arylsulfatase AtsD -
TM57_RS12260 2584321..2584575 + 255 WP_003911263.1 antitoxin VapB7 -
TM57_RS12265 2584572..2585009 + 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
TM57_RS12270 2585119..2585364 + 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
TM57_RS12275 2585351..2585659 + 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
TM57_RS12280 2585935..2586651 + 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
TM57_RS12285 2586727..2586882 + 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
TM57_RS12290 2586977..2587360 + 384 WP_003403365.1 ribonuclease VapC6 -
TM57_RS12295 2587748..2588758 - 1011 WP_003911248.1 ABC transporter ATP-binding protein -
TM57_RS12300 2588839..2590344 - 1506 WP_003403360.1 carotenoid cleavage oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T54410 WP_003403386.1 NZ_CP011510:2584572-2585009 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T54410 NZ_CP011510:2584572-2585009 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT54410 WP_003403381.1 NZ_CP011510:2585119-2585364 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT54410 NZ_CP011510:2585119-2585364 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References