Detailed information of TA system TA054403

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1960003..1960691
• Replicon: chromosome
• Accession: NZ_CP011510
• Organism: Mycobacterium tuberculosis strain Beijing

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: TM57_RS09160
• Protein ID: WP_003406304.1
• Coordinates: 1960003..1960434 (-)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: TM57_RS09165
• Protein ID: WP_003406302.1
• Coordinates: 1960431..1960691 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TM57_RS09135	1955830..1956099	+	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
TM57_RS09140	1956096..1956389	+	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
TM57_RS09145	1956446..1957276	+	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
TM57_RS09150	1957357..1958217	-	861	WP_003900301.1	hypothetical protein	-
TM57_RS09155	1958397..1959980	+	1584	WP_009940130.1	PE family protein	-
TM57_RS09160	1960003..1960434	-	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
TM57_RS09165	1960431..1960691	-	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
TM57_RS09170	1960767..1961756	-	990	WP_003406301.1	malate dehydrogenase	-
TM57_RS09175	1961927..1963027	+	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
TM57_RS09180	1963104..1964285	-	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
TM57_RS09185	1964290..1965114	-	825	WP_003900298.1	trehalose ABC transporter permease SugB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T54403 WP_003406304.1 NZ_CP011510:c1960434-1960003 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T54403 NZ_CP011510:c1960434-1960003 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT54403 WP_003406302.1 NZ_CP011510:c1960691-1960431 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT54403 NZ_CP011510:c1960691-1960431 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6