Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1157420..1157964 Replicon chromosome
Accession NZ_CP011510
Organism Mycobacterium tuberculosis strain Beijing

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag TM57_RS05550 Protein ID WP_003409896.1
Coordinates 1157668..1157964 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag TM57_RS05545 Protein ID WP_003409899.1
Coordinates 1157420..1157671 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TM57_RS05515 1153147..1153944 - 798 WP_003899101.1 ABC transporter permease -
TM57_RS05525 1154843..1156063 + 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
TM57_RS05530 1156096..1156368 + 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
TM57_RS05535 1156372..1156779 + 408 WP_069984916.1 type II toxin-antitoxin system VapC family toxin -
TM57_RS05540 1156939..1157433 - 495 WP_003899099.1 hypothetical protein -
TM57_RS05545 1157420..1157671 + 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
TM57_RS05550 1157668..1157964 + 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TM57_RS05555 1158013..1158627 + 615 WP_003901296.1 hypothetical protein -
TM57_RS05560 1158516..1159061 - 546 WP_003409891.1 SecB-like chaperone -
TM57_RS05565 1159058..1159507 - 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
TM57_RS05570 1159549..1159926 - 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
TM57_RS22120 1159901..1160422 + 522 WP_003904745.1 hypothetical protein -
TM57_RS05580 1160396..1160707 - 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
TM57_RS05585 1160704..1160919 - 216 WP_003409878.1 antitoxin -
TM57_RS05590 1161159..1161455 + 297 WP_003409877.1 hypothetical protein -
TM57_RS05595 1161456..1161647 + 192 WP_003409876.1 hypothetical protein -
TM57_RS05600 1161668..1162570 + 903 WP_069984917.1 hypothetical protein -
TM57_RS05605 1162581..1162931 + 351 WP_003409871.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T54393 WP_003409896.1 NZ_CP011510:1157668-1157964 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T54393 NZ_CP011510:1157668-1157964 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT54393 WP_003409899.1 NZ_CP011510:1157420-1157671 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT54393 NZ_CP011510:1157420-1157671 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References