Detailed information of TA system TA054387

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 991394..992204
• Replicon: chromosome
• Accession: NZ_CP011510
• Organism: Mycobacterium tuberculosis strain Beijing

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: TM57_RS04770
• Protein ID: WP_069984977.1
• Coordinates: 991740..992204 (+)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TMN0
• Locus tag: TM57_RS04765
• Protein ID: WP_003410814.1
• Coordinates: 991394..991648 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TM57_RS04735	986742..986936	+	195	WP_003411026.1	ubiquitin-like protein Pup	-
TM57_RS04740	986933..987808	+	876	WP_003411023.1	proteasome subunit beta	-
TM57_RS04745	987805..988551	+	747	WP_003901330.1	proteasome subunit alpha	-
TM57_RS04750	989091..989822	-	732	WP_003900467.1	PPE family protein	-
TM57_RS04755	989878..990174	-	297	WP_003410820.1	PE family protein	-
TM57_RS04760	991121..991378	+	258	WP_003410816.1	hypothetical protein	-
TM57_RS04765	991394..991648	+	255	WP_003410814.1	antitoxin	Antitoxin
TM57_RS21805	991655..991780	+	126	Protein_936	type II toxin-antitoxin system VapC family toxin	-
TM57_RS04770	991740..992204	+	465	WP_069984977.1	type II toxin-antitoxin system VapC family toxin	Toxin
TM57_RS04775	992183..993016	-	834	WP_003899172.1	SWIM zinc finger family protein	-
TM57_RS04780	993009..996050	-	3042	WP_003899171.1	DEAD/DEAH box helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (14-152)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 16533.96 Da
• Isoelectric Point: 7.9324

>T54387 WP_069984977.1 NZ_CP011510:991740-992204 [Mycobacterium tuberculosis]
VRCRAPTASGSPGCDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQV
ADWLAAPSAVLVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Nucleotide

• Length: 465 bp

>T54387 NZ_CP011510:991740-992204 [Mycobacterium tuberculosis]
GTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAG
TGAGCACCACAAGCCGTCGCTGCGCTGGCTTGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGT
TGTTGGCGTTCGTGCGATTGGCGACCAAGGTGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTC
GCGGATTGGCTAGCCGCACCCAGCGCCGTCTTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGAC
GTACGTGGGAACCGGTGCCAACCTGGTCAACGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGT
CCTACGACAGTGACTTCGGCCGATTCGAAGGGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9417.57 Da
• Isoelectric Point: 8.9912

>AT54387 WP_003410814.1 NZ_CP011510:991394-991648 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Nucleotide

• Length: 255 bp

>AT54387 NZ_CP011510:991394-991648 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Structures

Antitoxin

• AlphaFold DB: G0TMN0