Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 954928..955457 Replicon chromosome
Accession NZ_CP011510
Organism Mycobacterium tuberculosis strain Beijing

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag TM57_RS04560 Protein ID WP_003411124.1
Coordinates 955140..955457 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag TM57_RS04555 Protein ID WP_003411127.1
Coordinates 954928..955143 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TM57_RS04525 950034..950810 + 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -
TM57_RS04530 950876..951532 + 657 WP_003411133.1 cell division protein SepF -
TM57_RS04535 951694..951984 + 291 WP_003900476.1 YggT family protein -
TM57_RS04540 952252..953034 + 783 WP_003411131.1 cell wall synthesis protein Wag31 -
TM57_RS04545 953129..953485 + 357 WP_003411130.1 hypothetical protein -
TM57_RS04550 953615..954673 - 1059 WP_003411129.1 hypothetical protein -
TM57_RS04555 954928..955143 + 216 WP_003411127.1 antitoxin ParD2 Antitoxin
TM57_RS04560 955140..955457 + 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TM57_RS04570 955870..957216 + 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
TM57_RS04575 957264..957794 + 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
TM57_RS04580 957799..958872 - 1074 WP_069984976.1 quinone-dependent dihydroorotate dehydrogenase -
TM57_RS04585 958908..959189 - 282 WP_003411112.1 hypothetical protein -
TM57_RS04590 959186..960262 - 1077 WP_003411110.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T54386 WP_003411124.1 NZ_CP011510:955140-955457 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T54386 NZ_CP011510:955140-955457 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT54386 WP_003411127.1 NZ_CP011510:954928-955143 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT54386 NZ_CP011510:954928-955143 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References