Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 438334..439048 Replicon chromosome
Accession NZ_CP011510
Organism Mycobacterium tuberculosis strain Beijing

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag TM57_RS02140 Protein ID WP_003413460.1
Coordinates 438334..438774 (-) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag TM57_RS02145 Protein ID WP_003413456.1
Coordinates 438761..439048 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TM57_RS02115 434246..434920 - 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -
TM57_RS02120 435048..435947 + 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
TM57_RS02125 435976..436821 + 846 WP_003413466.1 acyl-CoA thioesterase II -
TM57_RS02130 436829..437425 + 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
TM57_RS02135 437558..438313 + 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
TM57_RS02140 438334..438774 - 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
TM57_RS02145 438761..439048 - 288 WP_003413456.1 antitoxin VapB41 Antitoxin
TM57_RS02150 439159..440730 - 1572 WP_003899392.1 polyamine aminopropyltransferase -
TM57_RS02155 440727..441185 - 459 WP_003413451.1 DUF350 domain-containing protein -
TM57_RS02160 441210..441641 - 432 WP_003899390.1 DUF4247 domain-containing protein -
TM57_RS02165 441638..442132 - 495 WP_003413444.1 DUF2617 family protein -
TM57_RS02170 442143..442763 - 621 WP_003413441.1 DUF4178 domain-containing protein -
TM57_RS02175 442980..443384 - 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
TM57_RS02180 443381..443626 - 246 WP_069984903.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T54380 WP_003413460.1 NZ_CP011510:c438774-438334 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T54380 NZ_CP011510:c438774-438334 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT54380 WP_003413456.1 NZ_CP011510:c439048-438761 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT54380 NZ_CP011510:c439048-438761 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References