Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1573316..1573880 Replicon chromosome
Accession NZ_CP011507
Organism Pseudomonas trivialis strain IHBB745

Toxin (Protein)


Gene name relE Uniprot ID A0A0H5AZU7
Locus tag AA957_RS06940 Protein ID WP_049713401.1
Coordinates 1573599..1573880 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0H5A4L9
Locus tag AA957_RS06935 Protein ID WP_049709531.1
Coordinates 1573316..1573603 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA957_RS06905 1568481..1570103 + 1623 WP_049709526.1 methyl-accepting chemotaxis protein -
AA957_RS06910 1570187..1570399 + 213 WP_049709527.1 cysteine-rich CWC family protein -
AA957_RS06915 1570399..1571091 + 693 WP_049709528.1 pseudouridine synthase -
AA957_RS06920 1571397..1572281 + 885 WP_049709529.1 alpha/beta hydrolase -
AA957_RS06930 1572905..1573246 + 342 WP_049709530.1 hypothetical protein -
AA957_RS06935 1573316..1573603 + 288 WP_049709531.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AA957_RS06940 1573599..1573880 + 282 WP_049713401.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AA957_RS06945 1573912..1574319 - 408 WP_049709532.1 hypothetical protein -
AA957_RS06950 1574316..1574903 - 588 WP_200904686.1 DUF433 domain-containing protein -
AA957_RS30615 1575392..1575523 - 132 WP_094030725.1 YHYH domain-containing protein -
AA957_RS06955 1575847..1576065 + 219 WP_049713402.1 Arc family DNA-binding protein -
AA957_RS06960 1576169..1576693 + 525 WP_049709534.1 DUF3833 domain-containing protein -
AA957_RS06965 1576717..1577022 + 306 WP_049709535.1 hypothetical protein -
AA957_RS06970 1577102..1577341 - 240 WP_049709536.1 hypothetical protein -
AA957_RS06975 1577666..1578856 - 1191 WP_049709537.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10799.64 Da        Isoelectric Point: 10.1967

>T54367 WP_049713401.1 NZ_CP011507:1573599-1573880 [Pseudomonas trivialis]
IEYEVEWDPKALKELKKLDGTIRLQFLKKLQERQAGPRVPGDALHGMKDCYKIKLRGAGYRLVYRVEDDRIVILVLAVGK
RERSSVYEQAGKR

Download         Length: 282 bp

>T54367 NZ_CP011507:1573599-1573880 [Pseudomonas trivialis]
ATTGAGTACGAAGTCGAGTGGGATCCGAAAGCGCTGAAGGAGCTGAAAAAGCTCGACGGGACAATACGTCTCCAGTTTCT
GAAAAAGCTCCAGGAGCGGCAGGCCGGCCCGCGAGTGCCAGGCGATGCACTTCATGGCATGAAGGATTGCTACAAGATCA
AATTGCGCGGCGCCGGCTACCGACTTGTGTACCGCGTTGAGGACGATCGGATTGTCATCCTCGTGCTGGCGGTCGGCAAG
CGAGAGCGCAGTTCGGTGTACGAGCAGGCAGGGAAGCGATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10246.72 Da        Isoelectric Point: 4.4328

>AT54367 WP_049709531.1 NZ_CP011507:1573316-1573603 [Pseudomonas trivialis]
MQNILADVAVSVSELKKNPSSVLSGANGLPVAVLNHNRVMGYMVPANVYEAMVERLDELELVHLVKARLDANETPVRVSL
DDLIGEAEVDIANGH

Download         Length: 288 bp

>AT54367 NZ_CP011507:1573316-1573603 [Pseudomonas trivialis]
ATGCAAAATATTCTGGCTGACGTGGCTGTCAGCGTATCCGAACTGAAGAAGAACCCCTCCTCCGTCTTGAGTGGTGCCAA
CGGCCTGCCAGTAGCCGTGCTGAACCACAACCGCGTTATGGGCTACATGGTTCCCGCAAATGTCTACGAAGCGATGGTAG
AGCGTCTGGACGAGCTGGAACTGGTTCACCTGGTCAAGGCTCGTCTCGACGCTAACGAAACACCTGTTCGGGTATCCCTC
GACGATCTCATTGGCGAGGCCGAGGTAGACATCGCCAATGGCCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H5AZU7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H5A4L9

References