54366

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1215695..1216299 Replicon chromosome
Accession NZ_CP011507
Organism Pseudomonas trivialis strain IHBB745

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H5A6F2
Locus tag AA957_RS05265 Protein ID WP_026136468.1
Coordinates 1216111..1216299 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H5AN32
Locus tag AA957_RS05260 Protein ID WP_049709253.1
Coordinates 1215695..1216099 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA957_RS05240 1210704..1211708 + 1005 WP_049709250.1 sulfate ABC transporter substrate-binding protein -
AA957_RS05245 1211844..1212458 - 615 WP_049709251.1 hypothetical protein -
AA957_RS05250 1212634..1213830 + 1197 WP_082224338.1 MFS transporter -
AA957_RS05255 1213806..1215389 - 1584 WP_082224340.1 M10 family metallopeptidase C-terminal domain-containing protein -
AA957_RS05260 1215695..1216099 - 405 WP_049709253.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AA957_RS05265 1216111..1216299 - 189 WP_026136468.1 type II toxin-antitoxin system HicA family toxin Toxin
AA957_RS05270 1216490..1217368 + 879 WP_049709254.1 LysR family transcriptional regulator -
AA957_RS05275 1217357..1218478 - 1122 WP_049709255.1 cytochrome P450 -
AA957_RS05280 1218553..1219248 + 696 WP_049709256.1 ArsR family transcriptional regulator -
AA957_RS05285 1219535..1220107 - 573 WP_049709257.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
AA957_RS05290 1220400..1220795 - 396 WP_049709258.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7220.41 Da        Isoelectric Point: 10.8676

>T54366 WP_026136468.1 NZ_CP011507:c1216299-1216111 [Pseudomonas trivialis]
VQSRLLIKELQEAGWVLDRVTGSHHIFTHRYNPYTIPVPHPKKDLPLGTVRSIRKRAGLFEF

Download         Length: 189 bp

>T54366 NZ_CP011507:c1216299-1216111 [Pseudomonas trivialis]
GTGCAAAGCAGGTTATTGATCAAGGAACTGCAAGAGGCAGGCTGGGTGTTGGATCGAGTTACGGGCAGTCATCATATATT
CACCCACCGCTATAACCCGTACACGATCCCCGTTCCCCATCCTAAAAAGGATTTGCCGCTGGGCACCGTCAGAAGCATCA
GGAAACGCGCCGGCCTGTTTGAGTTTTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14655.59 Da        Isoelectric Point: 4.5902

>AT54366 WP_049709253.1 NZ_CP011507:c1216099-1215695 [Pseudomonas trivialis]
MQYPICIEWGDDFTATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHILLQEIAAEGGPVPMPTSVANHHAHDDYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRS

Download         Length: 405 bp

>AT54366 NZ_CP011507:c1216099-1215695 [Pseudomonas trivialis]
ATGCAATACCCAATCTGTATCGAATGGGGCGATGACTTTACCGCCACCGGTATCCAGATCCCCGATATCCCAGGCGCAGT
CACCGCCGGGGACAGTTTTGAAGAGGCCTACAACGCCGCTGTGGAAGTCGCCCACATCCTGTTGCAGGAGATCGCCGCAG
AGGGCGGGCCGGTACCGATGCCAACGTCGGTGGCCAACCATCACGCGCACGACGACTACGCCGGGATGGGCTGGGGGATG
CTGGAGTTGGACATCTCGCCCTACTTGGGCAAGACCGAGAAGGTCAATGTGACCTTGCCCGGTTATGTGATCCAGCGCAT
CGACCGTTATGTGCGTGAGCACAAGGTCAAAAGCCGCTCTTCCTTTCTCGCCGATGCCGCGCTTGAGAAGTTGGTGCGGT
CCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H5A6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H5AN32

References