Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 605194..605807 Replicon chromosome
Accession NZ_CP011507
Organism Pseudomonas trivialis strain IHBB745

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H5A2F1
Locus tag AA957_RS02435 Protein ID WP_049708753.1
Coordinates 605194..605445 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H5A658
Locus tag AA957_RS02440 Protein ID WP_049708754.1
Coordinates 605442..605807 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA957_RS02435 605194..605445 + 252 WP_049708753.1 type II toxin-antitoxin system HicA family toxin Toxin
AA957_RS02440 605442..605807 + 366 WP_049708754.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AA957_RS02445 605808..606980 - 1173 WP_049708755.1 MFS transporter -
AA957_RS02450 607122..607709 + 588 WP_049708756.1 TetR/AcrR family transcriptional regulator -
AA957_RS02455 607693..609048 - 1356 WP_049708757.1 MATE family efflux transporter -
AA957_RS31260 609253..610386 - 1134 WP_200904666.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9561.14 Da        Isoelectric Point: 10.3136

>T54365 WP_049708753.1 NZ_CP011507:605194-605445 [Pseudomonas trivialis]
VSKNEKLLAKLLNEHMAFTWPERVTLLRRLGYTQIEGAGSRVKFDIGDPSAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

>T54365 NZ_CP011507:605194-605445 [Pseudomonas trivialis]
GTGTCCAAAAATGAAAAGCTGCTCGCCAAACTGCTCAACGAGCACATGGCATTTACCTGGCCCGAACGCGTCACGCTGCT
GCGTCGGCTCGGCTACACACAGATTGAAGGGGCTGGAAGCCGCGTCAAATTCGACATCGGTGACCCCAGTGCAATGATCA
CCTTGCACAAGCCTCACCCTGGTAACGAACTGAAACACTACATTCGGCGCCAGATCATCGAACAATTGAAATCAGGAGAA
CTGATTCAGTGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13179.01 Da        Isoelectric Point: 7.0277

>AT54365 WP_049708754.1 NZ_CP011507:605442-605807 [Pseudomonas trivialis]
VNNQLKHKGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDAAFREAVDDYLATCQTLGHTPEKPCKGSFNVRVGH
DLHLAAALAATRKKVTLNDLTRQALNEFLQHHSADTCPALG

Download         Length: 366 bp

>AT54365 NZ_CP011507:605442-605807 [Pseudomonas trivialis]
GTGAACAACCAACTGAAACACAAAGGCTACATCGGCTCTATCGAAGCCAGCCTCGAAGACAACTGCCTGTTCGGCAAGAT
CCTGTTCATCAAGGCGCTGGTGAGCTATGAAGGCAAAACCGTTGCCGAATTGGACGCCGCATTTCGTGAGGCGGTGGACG
ACTACCTCGCCACCTGCCAGACCCTGGGGCACACACCGGAGAAGCCTTGCAAAGGTTCCTTCAATGTCCGGGTCGGCCAT
GATCTGCACTTGGCGGCGGCCCTGGCGGCAACCCGCAAGAAAGTGACGCTCAATGACCTGACACGCCAAGCGCTGAATGA
GTTTTTGCAGCACCACAGTGCAGATACTTGCCCGGCGCTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H5A2F1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H5A658

References