Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 543097..543683 Replicon chromosome
Accession NZ_CP011505
Organism Burkholderia pyrrocinia strain DSM 10685

Toxin (Protein)


Gene name vapC Uniprot ID A0A0G3X214
Locus tag ABD05_RS32605 Protein ID WP_047904263.1
Coordinates 543300..543683 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0G3X6C0
Locus tag ABD05_RS32600 Protein ID WP_047904686.1
Coordinates 543097..543303 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABD05_RS32590 539616..541037 + 1422 WP_047904262.1 HlyD family type I secretion periplasmic adaptor subunit -
ABD05_RS32595 541168..542502 + 1335 WP_082146320.1 TolC family protein -
ABD05_RS32600 543097..543303 + 207 WP_047904686.1 DUF2191 domain-containing protein Antitoxin
ABD05_RS32605 543300..543683 + 384 WP_047904263.1 PIN domain-containing protein Toxin
ABD05_RS32610 544120..544434 + 315 WP_047904264.1 hypothetical protein -
ABD05_RS32620 545122..545418 - 297 WP_047904266.1 H-NS histone family protein -
ABD05_RS32625 545739..546497 + 759 WP_047904267.1 hypothetical protein -
ABD05_RS32630 546559..548154 + 1596 WP_148669196.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 519335..544877 25542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-114)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14339.71 Da        Isoelectric Point: 7.2933

>T54363 WP_047904263.1 NZ_CP011505:543300-543683 [Burkholderia pyrrocinia]
MSVLVDTSVWVEHFRRPLPALIQLLRVDNVLTHPLVILELTCGTPPEPRARTLGDLALLRQTRLATPGEVADWIERERLY
GRGCGAVDCTLLASVLLTPSTRLWTRDRRLVQLAEQFGVHYVPPDLH

Download         Length: 384 bp

>T54363 NZ_CP011505:543300-543683 [Burkholderia pyrrocinia]
ATGAGTGTCTTGGTCGACACGTCAGTGTGGGTCGAGCATTTCCGGCGGCCACTACCGGCGCTTATCCAGCTTCTGCGCGT
CGATAACGTCCTGACGCATCCACTGGTGATACTCGAGCTCACGTGTGGGACGCCGCCCGAACCGCGGGCTCGAACGCTGG
GGGATCTCGCGTTATTGCGCCAAACGCGCCTCGCGACGCCAGGCGAAGTAGCGGACTGGATCGAGCGGGAACGGCTGTAT
GGGCGCGGATGCGGTGCGGTGGATTGCACGCTGCTGGCATCGGTGCTGTTGACCCCGAGCACCCGCCTCTGGACGCGCGA
TCGCCGGCTCGTGCAACTGGCGGAGCAATTCGGGGTTCACTACGTACCGCCTGACCTGCATTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7339.44 Da        Isoelectric Point: 6.2465

>AT54363 WP_047904686.1 NZ_CP011505:543097-543303 [Burkholderia pyrrocinia]
MRTTVTVDDTLYARALELAEPGMLPADLFRAALETFVRVQAGQRLAALGGRAPDMADVPRRAPEATAR

Download         Length: 207 bp

>AT54363 NZ_CP011505:543097-543303 [Burkholderia pyrrocinia]
ATGCGTACCACCGTCACCGTCGACGACACTCTCTATGCGCGCGCACTCGAACTCGCCGAACCGGGCATGCTGCCGGCCGA
CCTGTTCCGGGCGGCACTGGAAACGTTCGTTCGTGTCCAGGCCGGCCAACGCCTGGCCGCCCTGGGCGGTCGCGCGCCCG
ACATGGCAGATGTCCCTCGCCGCGCCCCTGAGGCAACCGCCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3X214

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3X6C0

References