Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3175682..3176328 Replicon chromosome
Accession NZ_CP011504
Organism Burkholderia pyrrocinia strain DSM 10685

Toxin (Protein)


Gene name vapC Uniprot ID A0A0G3X008
Locus tag ABD05_RS30175 Protein ID WP_047903578.1
Coordinates 3175682..3176089 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0G3X2K3
Locus tag ABD05_RS30180 Protein ID WP_047903579.1
Coordinates 3176086..3176328 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABD05_RS30160 3171546..3172118 - 573 WP_047903576.1 hypothetical protein -
ABD05_RS30165 3172115..3172843 - 729 WP_047903899.1 chemotaxis protein -
ABD05_RS30170 3172866..3175250 - 2385 WP_047903577.1 MCP four helix bundle domain-containing protein -
ABD05_RS30175 3175682..3176089 - 408 WP_047903578.1 type II toxin-antitoxin system VapC family toxin Toxin
ABD05_RS30180 3176086..3176328 - 243 WP_047903579.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ABD05_RS30185 3176589..3177272 + 684 WP_047903580.1 phospholipase -
ABD05_RS30190 3177324..3178829 - 1506 WP_047903581.1 amino acid permease -
ABD05_RS30195 3178932..3180338 - 1407 WP_047903582.1 aspartate ammonia-lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14848.08 Da        Isoelectric Point: 6.3304

>T54362 WP_047903578.1 NZ_CP011504:c3176089-3175682 [Burkholderia pyrrocinia]
MKFLLDTNAVIAILKGEPAMLARLRPHQPADFGIPAIVAHELYYGAYKSQRVAANVARVEALQFEVVSFDVEDAQHAGEI
RAHLIAAGTPIGPYDALIAGQARARQLVLVTHNIREFERVPGLQVEDWLAVPRES

Download         Length: 408 bp

>T54362 NZ_CP011504:c3176089-3175682 [Burkholderia pyrrocinia]
ATGAAGTTCCTGCTGGATACCAACGCGGTGATCGCCATACTCAAAGGCGAGCCGGCCATGCTGGCCCGACTGCGGCCGCA
CCAGCCGGCCGATTTCGGGATACCGGCGATCGTCGCGCATGAACTCTATTACGGCGCCTACAAAAGCCAGCGCGTGGCTG
CGAACGTGGCGCGTGTCGAGGCGCTTCAGTTCGAGGTCGTATCGTTCGATGTCGAGGATGCGCAGCATGCCGGCGAAATT
CGGGCGCATCTGATCGCGGCCGGTACGCCGATCGGCCCTTACGACGCATTGATCGCAGGGCAGGCGCGCGCCCGGCAACT
GGTGCTTGTCACGCATAACATCCGGGAATTCGAGCGTGTCCCCGGGCTGCAAGTCGAAGACTGGCTCGCTGTGCCCCGCG
AAAGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8919.09 Da        Isoelectric Point: 5.0348

>AT54362 WP_047903579.1 NZ_CP011504:c3176328-3176086 [Burkholderia pyrrocinia]
MDIAKIFKHGGSQAVRLPKDFRFETTEVRIRRHGASVILEPVPQDWAWLTPLIGPVDADFEAAATTQPSAQERSGLDVFE

Download         Length: 243 bp

>AT54362 NZ_CP011504:c3176328-3176086 [Burkholderia pyrrocinia]
ATGGATATTGCCAAGATCTTCAAGCATGGCGGATCGCAGGCTGTCAGGCTGCCGAAGGATTTCCGCTTCGAGACGACCGA
GGTCCGGATTCGTCGCCACGGGGCGTCCGTCATTCTCGAGCCGGTGCCGCAAGACTGGGCATGGCTGACGCCGCTGATCG
GTCCGGTCGACGCCGATTTCGAGGCAGCCGCGACCACGCAGCCATCCGCTCAGGAACGGTCGGGCCTGGACGTATTCGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3X008

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3X2K3

References