Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3151639..3152216 Replicon chromosome
Accession NZ_CP011504
Organism Burkholderia pyrrocinia strain DSM 10685

Toxin (Protein)


Gene name vapC Uniprot ID A0A0G3WZY9
Locus tag ABD05_RS30065 Protein ID WP_047903560.1
Coordinates 3151851..3152216 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2S8IKU8
Locus tag ABD05_RS30060 Protein ID WP_034179821.1
Coordinates 3151639..3151857 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABD05_RS30035 3146924..3147403 + 480 WP_047903555.1 GNAT family N-acetyltransferase -
ABD05_RS30040 3147485..3148735 - 1251 WP_047903556.1 Zn-dependent hydrolase -
ABD05_RS30045 3148728..3149252 - 525 WP_047903557.1 L-2-amino-thiazoline-4-carboxylic acid hydrolase -
ABD05_RS30050 3149271..3150437 - 1167 WP_047903558.1 branched-chain amino acid ABC transporter substrate-binding protein -
ABD05_RS30055 3150615..3151511 + 897 WP_047903559.1 LysR family transcriptional regulator -
ABD05_RS30060 3151639..3151857 + 219 WP_034179821.1 hypothetical protein Antitoxin
ABD05_RS30065 3151851..3152216 + 366 WP_047903560.1 type II toxin-antitoxin system VapC family toxin Toxin
ABD05_RS30070 3152606..3153169 + 564 WP_006488685.1 peroxiredoxin -
ABD05_RS30075 3153298..3154896 + 1599 WP_047903561.1 alkyl hydroperoxide reductase subunit F -
ABD05_RS30080 3155015..3155410 - 396 WP_047903562.1 type II toxin-antitoxin system VapC family toxin -
ABD05_RS30085 3155407..3155652 - 246 WP_047903563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
ABD05_RS30090 3155824..3156639 - 816 WP_047903564.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13513.53 Da        Isoelectric Point: 8.4940

>T54361 WP_047903560.1 NZ_CP011504:3151851-3152216 [Burkholderia pyrrocinia]
MVKALFDTNILIDYLGGVESARVELARYHYRAISTISWMEVLVGTSAHDEAPTRAWLSSFDVIALDSTIANRAVTIRKER
RIRLPDAIVWASAQVNGLLLVSRNTKDFPATEPGVRVPYQV

Download         Length: 366 bp

>T54361 NZ_CP011504:3151851-3152216 [Burkholderia pyrrocinia]
ATGGTAAAAGCTCTCTTCGACACCAACATCCTGATCGACTATCTGGGCGGCGTGGAATCCGCACGCGTAGAGTTGGCCCG
CTACCACTATCGTGCGATCAGCACGATCTCGTGGATGGAGGTCCTGGTCGGCACGTCCGCACATGACGAAGCCCCGACTC
GCGCATGGCTCTCGTCATTCGATGTCATCGCGCTCGACAGCACGATTGCGAATCGCGCCGTGACTATCCGCAAGGAACGC
CGCATACGCCTGCCCGACGCGATCGTCTGGGCATCGGCGCAAGTGAACGGGCTGCTGCTCGTGTCGCGCAACACGAAAGA
CTTTCCCGCCACCGAACCCGGCGTTCGCGTGCCCTATCAGGTCTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8313.46 Da        Isoelectric Point: 4.4419

>AT54361 WP_034179821.1 NZ_CP011504:3151639-3151857 [Burkholderia pyrrocinia]
MSRILVDLSDGQLDELAVIVETERRPRAAIIRDAIDAYIALHKRPLADDVFGLWKDRTVDGLAYQEEMRSEW

Download         Length: 219 bp

>AT54361 NZ_CP011504:3151639-3151857 [Burkholderia pyrrocinia]
ATGAGCCGGATTCTGGTTGATCTGTCGGATGGCCAGCTCGACGAGTTGGCCGTCATCGTCGAGACTGAACGTCGTCCCCG
CGCCGCGATCATCCGCGACGCGATTGATGCCTACATTGCCCTGCACAAGCGCCCGCTCGCCGACGACGTATTCGGTCTCT
GGAAAGATCGCACGGTCGATGGGCTCGCGTATCAGGAGGAAATGCGCTCGGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3WZY9

Antitoxin

Source ID Structure
AlphaFold DB A0A2S8IKU8

References