Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 2810756..2811389 Replicon chromosome
Accession NZ_CP011504
Organism Burkholderia pyrrocinia strain DSM 10685

Toxin (Protein)


Gene name vapC Uniprot ID A0A0G3X1S7
Locus tag ABD05_RS28580 Protein ID WP_047903297.1
Coordinates 2810756..2811169 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0G3X092
Locus tag ABD05_RS28585 Protein ID WP_047903298.1
Coordinates 2811156..2811389 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABD05_RS28560 2806589..2807896 + 1308 WP_047903873.1 shikimate transporter -
ABD05_RS28565 2808100..2809401 + 1302 WP_047903294.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
ABD05_RS28570 2809530..2810141 - 612 WP_047903295.1 hypothetical protein -
ABD05_RS28575 2810318..2810713 + 396 WP_047903296.1 DUF4440 domain-containing protein -
ABD05_RS28580 2810756..2811169 - 414 WP_047903297.1 PIN domain-containing protein Toxin
ABD05_RS28585 2811156..2811389 - 234 WP_047903298.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ABD05_RS28590 2811549..2812319 + 771 WP_047903299.1 helix-turn-helix domain-containing protein -
ABD05_RS28595 2812415..2814715 - 2301 WP_047903874.1 ATP-dependent DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(10-119)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15211.35 Da        Isoelectric Point: 5.1973

>T54360 WP_047903297.1 NZ_CP011504:c2811169-2810756 [Burkholderia pyrrocinia]
MSGVESAKSFVDSNVVLYLLSEDETKANRAEALFLRRPTVSVQVLNEVASVCSRKLRMPWSDVGQFLEPIRSLCHVVPVT
IDTHDLARRLAERHGLSFYDACIVAAASLEGCEYLYTEDMHDGLRVDGGPVLRNPFA

Download         Length: 414 bp

>T54360 NZ_CP011504:c2811169-2810756 [Burkholderia pyrrocinia]
ATGAGCGGGGTTGAGTCGGCGAAATCGTTCGTCGACAGCAATGTCGTGCTTTATCTGCTGTCCGAGGACGAAACCAAGGC
AAATCGCGCGGAGGCGCTGTTCCTTCGGCGGCCCACCGTCAGTGTCCAGGTACTGAACGAAGTCGCCAGCGTCTGCAGCC
GAAAATTGCGGATGCCGTGGAGCGACGTGGGGCAGTTTCTGGAACCGATCAGGAGCTTGTGCCATGTCGTACCGGTCACG
ATCGATACGCATGACCTGGCGCGAAGGCTCGCGGAGCGGCATGGCTTGTCCTTCTATGACGCGTGCATCGTCGCCGCCGC
GTCGCTCGAGGGTTGCGAGTACCTGTACACCGAGGACATGCACGACGGCCTGCGCGTGGACGGCGGTCCGGTGCTGCGAA
ATCCGTTTGCCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8777.03 Da        Isoelectric Point: 10.2843

>AT54360 WP_047903298.1 NZ_CP011504:c2811389-2811156 [Burkholderia pyrrocinia]
MQVAKWGNSLAVRLPASVVDALELREGDDIEIVVDSPRVFAVSRKPRPDELLQRLRRFRGKLPADFKFSRDDANERG

Download         Length: 234 bp

>AT54360 NZ_CP011504:c2811389-2811156 [Burkholderia pyrrocinia]
ATGCAAGTCGCAAAGTGGGGCAATAGCCTGGCCGTCCGCCTTCCCGCCAGTGTGGTTGATGCACTGGAGCTGCGCGAAGG
GGACGATATCGAAATCGTGGTCGATAGCCCGCGCGTTTTTGCCGTCAGTCGCAAGCCCAGGCCCGATGAACTTCTGCAAC
GGCTGCGGCGTTTCAGGGGCAAGCTGCCCGCCGATTTCAAGTTCAGCCGGGACGATGCGAATGAGCGGGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3X1S7

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3X092

References