Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2288968..2290798 Replicon chromosome
Accession NZ_CP011504
Organism Burkholderia pyrrocinia strain DSM 10685

Toxin (Protein)


Gene name doc Uniprot ID A0A0G3X1G7
Locus tag ABD05_RS26405 Protein ID WP_047902930.1
Coordinates 2288968..2289864 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0G3X0M8
Locus tag ABD05_RS26410 Protein ID WP_047902931.1
Coordinates 2289944..2290798 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABD05_RS26375 2284346..2285425 - 1080 WP_047902927.1 porin -
ABD05_RS26380 2285873..2286190 + 318 WP_027789384.1 non-heme iron oxygenase ferredoxin subunit -
ABD05_RS26385 2286192..2286503 + 312 WP_034180372.1 hypothetical protein -
ABD05_RS26390 2286559..2287629 + 1071 WP_047902928.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
ABD05_RS26395 2287622..2288392 + 771 WP_047902929.1 SDR family oxidoreductase -
ABD05_RS26400 2288422..2288949 + 528 WP_006489904.1 cupin domain-containing protein -
ABD05_RS26405 2288968..2289864 + 897 WP_047902930.1 alpha/beta fold hydrolase Toxin
ABD05_RS26410 2289944..2290798 + 855 WP_047902931.1 IclR family transcriptional regulator Antitoxin
ABD05_RS26415 2290795..2291592 + 798 WP_047902932.1 SDR family oxidoreductase -
ABD05_RS26420 2291585..2293252 + 1668 WP_047902933.1 thiamine pyrophosphate-binding protein -
ABD05_RS26425 2293245..2294060 + 816 WP_047902934.1 aspartate dehydrogenase -
ABD05_RS26430 2294150..2295640 + 1491 WP_047902935.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-277)

Antitoxin

Transcription regulator IclR, C-terminal

(142-265)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30650.88 Da        Isoelectric Point: 7.7327

>T54358 WP_047902930.1 NZ_CP011504:2288968-2289864 [Burkholderia pyrrocinia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPSVYSALIETFCRQCDTQWGLV

Download         Length: 897 bp

>T54358 NZ_CP011504:2288968-2289864 [Burkholderia pyrrocinia]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGTTATCGCGAGGCCGGCGCGCAGCATGCGGGCCGCGCGCTGCCGGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGCGCCAGCTCGACGCGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGTTATGGCGCGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCGTCGTTGAACGC
GTGGCTCGAGGCACTCGGCATCGAGCGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCGTCGCGGGCGGTCTCGCCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGCGCGCCCGCCGAAACGCGC
GAATCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAGCGAGGATGCGCGCGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGACCGATCTCGCCGGTTTTCGCGGCCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCAATTACGCCGCCCGCCGCATGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGTTGCAGGTGATTCCGCA
AGCCGGTCATGCCGGATACGTGGAAGCGCCGTCCGTTTATTCCGCACTGATCGAAACGTTCTGCCGTCAGTGCGATACGC
AGTGGGGTCTGGTATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31372.85 Da        Isoelectric Point: 6.5086

>AT54358 WP_047902931.1 NZ_CP011504:2289944-2290798 [Burkholderia pyrrocinia]
MSEPLQQEPENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAYATTHGHV
LMGDLSLKELRSLYPEGTLNRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVPR
PEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 855 bp

>AT54358 NZ_CP011504:2289944-2290798 [Burkholderia pyrrocinia]
ATGAGCGAACCGCTGCAACAAGAACCCGAAAACGGGAAGGCCGAAGCCAGCTACGTGGTGCCGGGCCTCGAACGCGGGCT
GCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAGTTGTCGAAACGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGTGCGGACAAGGATCGCAACTACAGGCTC
GGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGAGAG
CCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATTCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAGGCGCAGA
GCCAGTCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACCCGCTTGCCCGCGTATGCAACGACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTGAAGGAGCTGCGCTCGCTGTATCCGGAAGGCACGCTGAACCGGATGACGAGCGCGACGCC
GGAGACGGTCGATGCGTTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTATGGCGTCAGCAATTCGTCGTTCGAAC
GCGGCATCTCGGTGGTCACGGCGCCCGTGCGCAACGAGACGCAGAGGATCGTCGCGTGCATCACGGTGACGGTGCCGCGG
CCGGAGATCGACGCGGCGCTGATCGCGGACGGGTTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCGGCT
CAATTACCGCTCGGATGACGAGCACACGTTTCTTAAGGCGTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3X1G7

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3X0M8

References