Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2122676..2123331 Replicon chromosome
Accession NZ_CP011504
Organism Burkholderia pyrrocinia strain DSM 10685

Toxin (Protein)


Gene name vapC Uniprot ID A0A0G3X0G1
Locus tag ABD05_RS25680 Protein ID WP_047902814.1
Coordinates 2122912..2123331 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2S8IH63
Locus tag ABD05_RS25675 Protein ID WP_034180974.1
Coordinates 2122676..2122915 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABD05_RS25650 2117735..2117974 - 240 WP_047902809.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ABD05_RS25655 2118180..2118602 + 423 WP_047902810.1 amino acid-binding protein -
ABD05_RS25660 2118682..2119365 - 684 WP_047902811.1 Fe2+-dependent dioxygenase -
ABD05_RS25665 2119362..2120117 - 756 WP_047902812.1 sel1 repeat family protein -
ABD05_RS25670 2120121..2122364 - 2244 WP_047902813.1 TonB-dependent siderophore receptor -
ABD05_RS25675 2122676..2122915 + 240 WP_034180974.1 Arc family DNA-binding protein Antitoxin
ABD05_RS25680 2122912..2123331 + 420 WP_047902814.1 type II toxin-antitoxin system VapC family toxin Toxin
ABD05_RS25685 2123460..2124755 - 1296 WP_047902815.1 aspartate carbamoyltransferase -
ABD05_RS25690 2124989..2125123 + 135 WP_009688930.1 entericidin A/B family lipoprotein -
ABD05_RS25695 2125225..2125797 - 573 WP_047902816.1 hypothetical protein -
ABD05_RS25700 2125984..2126952 - 969 WP_047903802.1 DMT family transporter -
ABD05_RS25705 2127171..2127965 - 795 WP_047902817.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15230.59 Da        Isoelectric Point: 7.0193

>T54357 WP_047902814.1 NZ_CP011504:2122912-2123331 [Burkholderia pyrrocinia]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAVLPEGRRREWLHRSIEQRVVPLFRGRILPFDD
AASKAYASVRARARVAGNAIAPVDGFIAATADANGLIVATRDVAPFEAVGLRVIDPWAR

Download         Length: 420 bp

>T54357 NZ_CP011504:2122912-2123331 [Burkholderia pyrrocinia]
ATGATCCTTGTTGATACGAATGTCATTTCCGAACCGCTGCGACGCGAGCCGAGCGCAGCCGTGATCGAGTGGCTCGATGC
CCAGAACGTCGAGACGCTGTTTCTTGCCGCGATCAGTCTCGCGGAGATGCGATTCGGCGTGGCTGTATTGCCGGAAGGGC
GCAGGCGCGAGTGGCTGCATCGAAGCATCGAACAGCGTGTGGTGCCATTGTTTCGAGGCCGGATCCTGCCATTCGACGAT
GCGGCGAGCAAAGCGTATGCGAGCGTTCGGGCGCGGGCCCGTGTCGCAGGTAACGCGATCGCGCCTGTCGATGGTTTTAT
CGCCGCCACGGCAGATGCGAACGGCCTGATCGTGGCCACGCGCGACGTCGCACCGTTCGAGGCGGTGGGGCTTCGCGTGA
TCGATCCGTGGGCGCGGTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8707.89 Da        Isoelectric Point: 5.6864

>AT54357 WP_034180974.1 NZ_CP011504:2122676-2122915 [Burkholderia pyrrocinia]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTLLAEIGREAGGVDFDVQRDKTSTDPMSFE

Download         Length: 240 bp

>AT54357 NZ_CP011504:2122676-2122915 [Burkholderia pyrrocinia]
ATGCCGGTGATCACCGTTCGAAATTTGCCCGATGAAGTGCATCGCGCACTTCGGATTCGCGCGGCCCAGCACGGGCGCAG
CACCGAAGCCGAGGTACGTGACATTCTCGAGCAGGCCGTCCTGCCAGGCGGGCGGCTCAAGCTGGGAACGTTGCTGGCGG
AAATCGGGCGGGAGGCTGGGGGAGTCGATTTCGACGTCCAGCGCGACAAGACGTCAACCGATCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3X0G1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S8IH63

References