Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 2040110..2040633 Replicon chromosome
Accession NZ_CP011504
Organism Burkholderia pyrrocinia strain DSM 10685

Toxin (Protein)


Gene name relE Uniprot ID A0A0G3X101
Locus tag ABD05_RS25330 Protein ID WP_047902759.1
Coordinates 2040110..2040376 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0G3X080
Locus tag ABD05_RS25335 Protein ID WP_047902760.1
Coordinates 2040373..2040633 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABD05_RS25305 2035735..2036649 + 915 WP_047902755.1 LysR family transcriptional regulator -
ABD05_RS25310 2036707..2037306 + 600 WP_047902756.1 GNAT family N-acetyltransferase -
ABD05_RS25315 2037441..2038019 - 579 WP_047902757.1 DUF4142 domain-containing protein -
ABD05_RS25320 2038410..2039033 - 624 WP_047902758.1 HAD hydrolase-like protein -
ABD05_RS25325 2039051..2039782 - 732 Protein_1823 substrate-binding domain-containing protein -
ABD05_RS25330 2040110..2040376 - 267 WP_047902759.1 Txe/YoeB family addiction module toxin Toxin
ABD05_RS25335 2040373..2040633 - 261 WP_047902760.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
ABD05_RS25340 2040859..2041302 + 444 WP_047902761.1 GNAT family N-acetyltransferase -
ABD05_RS25345 2041360..2041578 + 219 WP_047902762.1 DUF1653 domain-containing protein -
ABD05_RS25350 2041587..2042045 - 459 WP_047902763.1 ATP synthase F1 subunit epsilon -
ABD05_RS25355 2042056..2042925 - 870 WP_047902764.1 ATP synthase F1 subunit gamma -
ABD05_RS25360 2043071..2044042 + 972 WP_047903791.1 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase -
ABD05_RS25365 2044053..2045261 + 1209 WP_047903792.1 acetate/propionate family kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10554.87 Da        Isoelectric Point: 7.9876

>T54356 WP_047902759.1 NZ_CP011504:c2040376-2040110 [Burkholderia pyrrocinia]
MSVRRVLFTSDAWDDYVYWQGQDRKTLRRINQLIREAQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADDLQISI
VSCRYHYE

Download         Length: 267 bp

>T54356 NZ_CP011504:c2040376-2040110 [Burkholderia pyrrocinia]
ATGAGCGTACGCCGCGTGCTCTTTACTTCCGACGCGTGGGACGACTATGTCTATTGGCAAGGGCAGGATCGCAAGACGCT
CAGGCGCATCAACCAGCTCATTCGCGAAGCCCAGCGGACGCCGTTCGAAGGCATCGGTAAACCCGAACCGTTAAAGGCCA
ATCTCTCCGGCTTCTGGTCGCGCCGTATCGACGACACGAACCGCCTGGTCTACGAGGCTGACGACCTTCAGATCAGCATC
GTGTCCTGCCGCTATCACTACGAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9775.03 Da        Isoelectric Point: 6.0717

>AT54356 WP_047902760.1 NZ_CP011504:c2040633-2040373 [Burkholderia pyrrocinia]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQDYYDSLMETVHLLRSPANVAHLERSIAQLRKGKTKEHK
LAEDDE

Download         Length: 261 bp

>AT54356 NZ_CP011504:c2040633-2040373 [Burkholderia pyrrocinia]
ATGCGCACGATTCATTTTTCGGATGCCCGCGGCAATCTGAAGACCGTCATCGACCAGGTCGTCGACGATGCGGACGTGAC
GCTCATCACGCGCCGCGATGCACCGAACGCCGTCATCATGTCGCAGGACTACTACGACAGCCTGATGGAGACGGTTCACT
TGCTGCGCTCGCCGGCCAACGTGGCCCATCTCGAACGTTCGATCGCGCAACTGCGCAAGGGCAAGACGAAAGAACACAAG
CTCGCCGAGGATGATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3X101

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3X080

References