Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 1866066..1867286 | Replicon | chromosome |
| Accession | NZ_CP011504 | ||
| Organism | Burkholderia pyrrocinia strain DSM 10685 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A0G3WX63 |
| Locus tag | ABD05_RS24530 | Protein ID | WP_047902621.1 |
| Coordinates | 1866066..1866647 (-) | Length | 194 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A0G3WZS9 |
| Locus tag | ABD05_RS24535 | Protein ID | WP_047902622.1 |
| Coordinates | 1866729..1867286 (-) | Length | 186 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ABD05_RS24515 | 1861174..1862547 | - | 1374 | WP_047902619.1 | efflux transporter outer membrane subunit | - |
| ABD05_RS24520 | 1862561..1864585 | - | 2025 | WP_047902620.1 | MacB family efflux pump subunit | - |
| ABD05_RS24525 | 1864588..1865781 | - | 1194 | WP_047903774.1 | efflux RND transporter periplasmic adaptor subunit | - |
| ABD05_RS24530 | 1866066..1866647 | - | 582 | WP_047902621.1 | HD domain-containing protein | Toxin |
| ABD05_RS24535 | 1866729..1867286 | - | 558 | WP_047902622.1 | helix-turn-helix domain-containing protein | Antitoxin |
| ABD05_RS24540 | 1867371..1868009 | - | 639 | WP_047902623.1 | hypothetical protein | - |
| ABD05_RS24545 | 1868375..1869778 | + | 1404 | WP_047902624.1 | membrane protein | - |
| ABD05_RS24550 | 1869873..1870451 | + | 579 | WP_047902625.1 | hypothetical protein | - |
| ABD05_RS24555 | 1870696..1871427 | + | 732 | WP_047902626.1 | ribonuclease T2 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 194 a.a. Molecular weight: 21344.88 Da Isoelectric Point: 4.9532
>T54355 WP_047902621.1 NZ_CP011504:c1866647-1866066 [Burkholderia pyrrocinia]
MNPDTIHARLDFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGTDTLKLLKLCVVHDLGEALHGDIP
AIEQAAYPDKSAHERDDLLTLTASLDRTLRDEIVALWDEYEAAASPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTQRRIDAGGHRA
MNPDTIHARLDFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGTDTLKLLKLCVVHDLGEALHGDIP
AIEQAAYPDKSAHERDDLLTLTASLDRTLRDEIVALWDEYEAAASPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTQRRIDAGGHRA
Download Length: 582 bp
>T54355 NZ_CP011504:c1866647-1866066 [Burkholderia pyrrocinia]
ATGAACCCCGACACGATCCACGCGCGCCTCGATTTCCTGCGCGAGGCCGAACGCCTGAAGGATGTGCTGCGCAGCGGCCA
CACATCGGCCGGGCGTGCGGAAAGCACGGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGATGCGC
TGCCCGGCACCGACACGCTGAAGCTGCTGAAGCTGTGTGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGTACCCCGACAAAAGCGCGCACGAACGCGACGACCTGCTGACGCTGACGGCGTCGCTCGATCG
CACGCTGCGCGACGAGATCGTCGCGCTGTGGGATGAATACGAGGCGGCCGCGTCGCCGGAAGCACGCGCGGCGAAGGCGC
TCGACAAGCTCGAGACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACCGATGCCGCGCCGCTGTTCAGTGCGATCCGCGATATCGTCGATGCCGATACGCAACGCAGGATCGA
CGCGGGTGGGCACCGCGCGTAA
ATGAACCCCGACACGATCCACGCGCGCCTCGATTTCCTGCGCGAGGCCGAACGCCTGAAGGATGTGCTGCGCAGCGGCCA
CACATCGGCCGGGCGTGCGGAAAGCACGGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGATGCGC
TGCCCGGCACCGACACGCTGAAGCTGCTGAAGCTGTGTGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGTACCCCGACAAAAGCGCGCACGAACGCGACGACCTGCTGACGCTGACGGCGTCGCTCGATCG
CACGCTGCGCGACGAGATCGTCGCGCTGTGGGATGAATACGAGGCGGCCGCGTCGCCGGAAGCACGCGCGGCGAAGGCGC
TCGACAAGCTCGAGACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACCGATGCCGCGCCGCTGTTCAGTGCGATCCGCGATATCGTCGATGCCGATACGCAACGCAGGATCGA
CGCGGGTGGGCACCGCGCGTAA
Antitoxin
Download Length: 186 a.a. Molecular weight: 20199.13 Da Isoelectric Point: 10.1931
>AT54355 WP_047902622.1 NZ_CP011504:c1867286-1866729 [Burkholderia pyrrocinia]
MTVSLLHTPPLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGIQQMSPDERATAERLLAARLDSAGDHALARLIAG
SAGRMHLVCDLTHRLLASSPARAAEFSQPLSMLLGTSLWRYATPEIVRMETALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSTCRWTRMTLSDGSAARLVETL
MTVSLLHTPPLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGIQQMSPDERATAERLLAARLDSAGDHALARLIAG
SAGRMHLVCDLTHRLLASSPARAAEFSQPLSMLLGTSLWRYATPEIVRMETALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSTCRWTRMTLSDGSAARLVETL
Download Length: 558 bp
>AT54355 NZ_CP011504:c1867286-1866729 [Burkholderia pyrrocinia]
ATGACCGTATCACTGCTTCACACGCCACCGCTCGGCCCGCAGCTCAAGCGCTGGCGCGCGCTGCACCGCGTGAAGCAAAG
CCACGCCGCAGAACTGTTCGGCGTCGCGCAATCGACGATCTCCCGCTGGGAAGCCGGCATCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCCGAGCGGCTGCTCGCCGCGCGCCTCGATTCCGCAGGCGACCATGCGCTCGCACGGCTCATCGCGGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTCGCCAGTTCGCCGGCGCGCGCGGCCGAGTTCTC
GCAACCGCTTTCGATGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACGCCGGAGATCGTCCGCATGGAAACCGCGCTCG
ACACGCTCGGCTGGCACGATCGCGCGGGGCCGCCGAGCGTCGAATTCGACACCGGCGCGAATGCATCGCGCGTCGTGCCG
ATCCGCGGCAGCACATGCCGGTGGACGCGGATGACGCTGTCGGACGGGTCGGCCGCACGGCTCGTGGAAACGCTTTAG
ATGACCGTATCACTGCTTCACACGCCACCGCTCGGCCCGCAGCTCAAGCGCTGGCGCGCGCTGCACCGCGTGAAGCAAAG
CCACGCCGCAGAACTGTTCGGCGTCGCGCAATCGACGATCTCCCGCTGGGAAGCCGGCATCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCCGAGCGGCTGCTCGCCGCGCGCCTCGATTCCGCAGGCGACCATGCGCTCGCACGGCTCATCGCGGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTCGCCAGTTCGCCGGCGCGCGCGGCCGAGTTCTC
GCAACCGCTTTCGATGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACGCCGGAGATCGTCCGCATGGAAACCGCGCTCG
ACACGCTCGGCTGGCACGATCGCGCGGGGCCGCCGAGCGTCGAATTCGACACCGGCGCGAATGCATCGCGCGTCGTGCCG
ATCCGCGGCAGCACATGCCGGTGGACGCGGATGACGCTGTCGGACGGGTCGGCCGCACGGCTCGTGGAAACGCTTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0G3WX63 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0G3WZS9 |