Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1335075..1335594 Replicon chromosome
Accession NZ_CP011504
Organism Burkholderia pyrrocinia strain DSM 10685

Toxin (Protein)


Gene name relE Uniprot ID A0A0G3WVZ2
Locus tag ABD05_RS22220 Protein ID WP_047902231.1
Coordinates 1335313..1335594 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0G3WYJ8
Locus tag ABD05_RS22215 Protein ID WP_047902230.1
Coordinates 1335075..1335323 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABD05_RS22205 1332341..1333534 + 1194 WP_047902228.1 2-methylaconitate cis-trans isomerase PrpF -
ABD05_RS22210 1333904..1334956 + 1053 WP_047902229.1 CoA transferase -
ABD05_RS22215 1335075..1335323 + 249 WP_047902230.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
ABD05_RS22220 1335313..1335594 + 282 WP_047902231.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ABD05_RS22225 1335651..1336094 - 444 WP_047902232.1 PaaI family thioesterase -
ABD05_RS22230 1336400..1338019 + 1620 WP_047902233.1 Tar ligand binding domain-containing protein -
ABD05_RS22235 1337992..1339101 - 1110 WP_047902234.1 AGE family epimerase/isomerase -
ABD05_RS22240 1339216..1339914 + 699 WP_047902235.1 MgtC/SapB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-78)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10939.83 Da        Isoelectric Point: 10.7091

>T54354 WP_047902231.1 NZ_CP011504:1335313-1335594 [Burkholderia pyrrocinia]
MTFELAFLEAALKEWKKLDRTVRDQFKARLAERLENPRIPSAKLHGHPDRYKIKLRSVGYRLVYEVRDSEVVVLVVAVGR
RERDAVYLAAMKR

Download         Length: 282 bp

>T54354 NZ_CP011504:1335313-1335594 [Burkholderia pyrrocinia]
ATGACCTTTGAGCTCGCCTTTCTCGAAGCTGCGTTGAAGGAGTGGAAGAAGCTCGATCGCACCGTTCGTGATCAGTTCAA
GGCCAGGCTCGCCGAACGGCTCGAGAATCCTCGCATTCCATCGGCGAAGCTGCACGGTCATCCGGACCGCTACAAGATCA
AGCTGCGCAGTGTCGGCTATCGCCTCGTGTACGAAGTGCGTGATTCGGAGGTCGTCGTACTGGTTGTCGCGGTGGGCCGT
CGCGAGCGCGATGCGGTCTATCTCGCCGCAATGAAACGCTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8935.26 Da        Isoelectric Point: 5.0636

>AT54354 WP_047902230.1 NZ_CP011504:1335075-1335323 [Burkholderia pyrrocinia]
MPHTILASVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALADSRAKEKAVKVKLN
DL

Download         Length: 249 bp

>AT54354 NZ_CP011504:1335075-1335323 [Burkholderia pyrrocinia]
ATGCCCCACACCATCCTGGCCAGCGTGACGGCGAGCGTCTCGGAGTTGAAGCGGAACCCGATGGGAACCGTGGCGGCGGG
AGAGGGCTTCCCGGTCGCGATCCTGAATCACAACGAACCCGCGTTCTATTGCATCCCGGCGAAGACATGGGAGGCGATGG
TCGAACGTCTTGAAGATATCGAAGACAACGCGCTGGCCGACTCGCGCGCCAAGGAGAAAGCCGTCAAGGTCAAGCTGAAT
GACCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3WVZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3WYJ8

References