Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 933478..934145 Replicon chromosome
Accession NZ_CP011504
Organism Burkholderia pyrrocinia strain DSM 10685

Toxin (Protein)


Gene name relE Uniprot ID A0A0G3X183
Locus tag ABD05_RS20425 Protein ID WP_047903683.1
Coordinates 933849..934145 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0G3WXQ3
Locus tag ABD05_RS20420 Protein ID WP_047901937.1
Coordinates 933478..933846 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABD05_RS20400 928840..929598 + 759 WP_047901933.1 ABC transporter permease -
ABD05_RS20405 929681..930706 + 1026 WP_047901934.1 fatty acid desaturase -
ABD05_RS20410 930950..932152 + 1203 WP_047901935.1 benzoate/H(+) symporter BenE family transporter -
ABD05_RS20415 932187..933074 - 888 WP_047901936.1 NAD(P)H-binding protein -
ABD05_RS20420 933478..933846 - 369 WP_047901937.1 putative addiction module antidote protein Antitoxin
ABD05_RS20425 933849..934145 - 297 WP_047903683.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ABD05_RS20430 934318..935217 - 900 WP_047901938.1 AraC family transcriptional regulator -
ABD05_RS20435 935410..935607 + 198 WP_047901939.1 hypothetical protein -
ABD05_RS20440 935629..936582 - 954 WP_047901940.1 LysR family transcriptional regulator -
ABD05_RS20445 936682..938046 + 1365 WP_047901941.1 NAD(P)/FAD-dependent oxidoreductase -
ABD05_RS20450 938372..938806 + 435 WP_047901942.1 phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(16-96)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10976.78 Da        Isoelectric Point: 9.1412

>T54353 WP_047903683.1 NZ_CP011504:c934145-933849 [Burkholderia pyrrocinia]
MFKVLTTPQFDEWLDKLWDPVGCAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIRVAKQIAGELED

Download         Length: 297 bp

>T54353 NZ_CP011504:c934145-933849 [Burkholderia pyrrocinia]
ATGTTCAAAGTCCTGACCACTCCCCAATTTGATGAATGGCTCGACAAGCTTTGGGACCCGGTCGGTTGCGCTGCGATCAA
CTTGCGCATCGAGCGGGCGAAGCTCGGCAACCTCGGCCAATGGCGGGCAGTCGGCGACGGCGTCAACGAAATGAAGATCG
ATGTAGGGCCGGGATATCGAGCCTACTTCGTGCGACGCGGGAAAATCATCGTCGTCGTGTTGTGCGGCGGGGACAAGTCG
ACACAGAAGAAGGACATCAGGGTGGCGAAGCAAATCGCCGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 12862.60 Da        Isoelectric Point: 9.5609

>AT54353 WP_047901937.1 NZ_CP011504:c933846-933478 [Burkholderia pyrrocinia]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGDPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVSALGLHLTVAPAAPATESASASAPAPTRARSRARPAAHA

Download         Length: 369 bp

>AT54353 NZ_CP011504:c933846-933478 [Burkholderia pyrrocinia]
ATGAAAATCAGCGAACTGGCCGAATTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAAGATGGGGATCCGCGACTGATCCAGGCCGCGCTCGGGAATGTCGCGAAGGCACGCGGCATGACGGCGCTGG
CGCGCGAATCTGGCGTGAAGCGTGAAGCGCTCTACCGCGCACTGTCGGAGGGTGGGAACGCCGAATTCGCAACGATCATG
AAGGTTGTCAGCGCGCTGGGATTGCACCTGACCGTTGCTCCGGCCGCGCCAGCGACCGAATCGGCGTCGGCGTCTGCTCC
CGCACCAACGCGTGCGCGTTCGCGCGCTCGCCCGGCGGCGCACGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3X183

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3WXQ3

References