Detailed information of TA system TA054351

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 306331..306972
• Replicon: chromosome
• Accession: NZ_CP011504
• Organism: Burkholderia pyrrocinia strain DSM 10685

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ABD05_RS17700
• Protein ID: WP_047901477.1
• Coordinates: 306331..306669 (+)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1J9PWC2
• Locus tag: ABD05_RS17705
• Protein ID: WP_039344756.1
• Coordinates: 306673..306972 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABD05_RS17690	302898..304331	-	1434	WP_047901475.1	aldehyde dehydrogenase family protein	-
ABD05_RS17695	304361..306001	-	1641	WP_047901476.1	acetolactate synthase large subunit	-
ABD05_RS17700	306331..306669	+	339	WP_047901477.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ABD05_RS17705	306673..306972	+	300	WP_039344756.1	putative addiction module antidote protein	Antitoxin
ABD05_RS17710	307354..307632	+	279	WP_047901478.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ABD05_RS17715	307645..307947	+	303	WP_047901479.1	HigA family addiction module antidote protein	-
ABD05_RS17720	307981..309267	-	1287	WP_047901480.1	DUF445 domain-containing protein	-
ABD05_RS17725	309479..310699	-	1221	WP_047901481.1	FAD-dependent oxidoreductase	-
ABD05_RS17730	310689..311015	-	327	WP_034185113.1	non-heme iron oxygenase ferredoxin subunit	-
ABD05_RS17735	311033..311509	-	477	WP_014900133.1	aromatic-ring-hydroxylating dioxygenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (26-98)

Antitoxin

• Uncharacterized protein HI1420 (6-93)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12625.51 Da
• Isoelectric Point: 8.9480

>T54351 WP_047901477.1 NZ_CP011504:306331-306669 [Burkholderia pyrrocinia]
MVDILQSMPYSAPTFSIRTTDVFDAWFAGLQDRVAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRG
TIWVILLCGGDKSTQQADIRAAHAMLAHLDME

Nucleotide

• Length: 339 bp

>T54351 NZ_CP011504:306331-306669 [Burkholderia pyrrocinia]
ATGGTTGACATACTGCAATCAATGCCCTACAGTGCGCCTACGTTCAGCATCCGGACCACCGACGTCTTCGACGCATGGTT
TGCCGGCCTGCAGGATCGCGTCGCGAAGCGCCGCATCCAGGCACGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACT
GGAAATCCGCCGGCTCGCCAGTCGTCGAAATGCGTATCGACCATGGCCCCGGTTATCGCGTCTACTACGTCCGGCGCGGA
ACGATCTGGGTCATCCTGCTCTGCGGCGGCGATAAATCGACGCAACAGGCCGACATACGCGCCGCGCACGCGATGCTTGC
GCATCTCGACATGGAGTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10649.01 Da
• Isoelectric Point: 6.3217

>AT54351 WP_039344756.1 NZ_CP011504:306673-306972 [Burkholderia pyrrocinia]
MDKISTRPWDSADHLKTEDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGSKAHA

Nucleotide

• Length: 300 bp

>AT54351 NZ_CP011504:306673-306972 [Burkholderia pyrrocinia]
ATGGACAAGATCAGCACCCGGCCGTGGGATTCGGCCGACCATCTGAAAACCGAAGACGACATGGCCGACTACTTCGAGGC
CTGCCTGCAAGAGGCCGGCGACGATCCGGCCTTCATCGCGCACGCGCTCGGCGTGATCGCACGCGCCCGCGGCATGTCGC
AGGTCGCGCGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAACCCGAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAACTGCACGGCTCGAAAGCGCACGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1J9PWC2