Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 3097607..3098141 Replicon chromosome
Accession NZ_CP011503
Organism Burkholderia pyrrocinia strain DSM 10685

Toxin (Protein)


Gene name parE Uniprot ID A0A0G3WTK1
Locus tag ABD05_RS14095 Protein ID WP_047900651.1
Coordinates 3097842..3098141 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0G3WRD7
Locus tag ABD05_RS14090 Protein ID WP_047900650.1
Coordinates 3097607..3097852 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABD05_RS14075 3094011..3095174 + 1164 WP_047900649.1 amidohydrolase -
ABD05_RS14080 3095387..3096709 - 1323 WP_167347847.1 DDE-type integrase/transposase/recombinase -
ABD05_RS14085 3096947..3097486 + 540 WP_047901214.1 outer membrane protein assembly factor BamE -
ABD05_RS14090 3097607..3097852 + 246 WP_047900650.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
ABD05_RS14095 3097842..3098141 + 300 WP_047900651.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ABD05_RS14100 3098233..3099537 - 1305 WP_047900652.1 cobyrinate a,c-diamide synthase -
ABD05_RS14105 3099540..3100142 - 603 WP_034184156.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
ABD05_RS14110 3100177..3100554 - 378 WP_047900653.1 cobalamin biosynthesis protein -
ABD05_RS14115 3100551..3101360 - 810 WP_175804795.1 uroporphyrinogen-III C-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11532.20 Da        Isoelectric Point: 7.4719

>T54350 WP_047900651.1 NZ_CP011503:3097842-3098141 [Burkholderia pyrrocinia]
MAVKGKQLRLTPLAELDLEDIWRYTAEHWSLAQADHYHRDLIGTIEALARGKKAGRTCIVRDGYFRYAVGSHVVFYREAD
DAIDVIRVLHQRMDIERHL

Download         Length: 300 bp

>T54350 NZ_CP011503:3097842-3098141 [Burkholderia pyrrocinia]
ATGGCGGTTAAAGGCAAGCAGCTTCGGCTGACACCGCTGGCCGAACTCGATCTCGAAGACATTTGGCGTTATACCGCCGA
GCATTGGTCGCTCGCGCAGGCAGACCACTATCATCGCGATCTGATCGGGACGATCGAAGCGCTGGCGCGCGGCAAGAAGG
CTGGTCGAACTTGCATTGTTCGGGATGGATATTTCCGGTACGCAGTTGGCTCTCACGTCGTGTTCTATCGCGAAGCGGAT
GACGCGATCGACGTGATTCGGGTCCTGCATCAGCGAATGGATATCGAACGACATCTGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8691.74 Da        Isoelectric Point: 8.7489

>AT54350 WP_047900650.1 NZ_CP011503:3097607-3097852 [Burkholderia pyrrocinia]
MSRNTSVSLGDHFAEFVDAQVQSGRYGSASDVVRAGLRLLESHETQMRALQEALKAGEASGAPKPFDSKAFLVRMRATHG
G

Download         Length: 246 bp

>AT54350 NZ_CP011503:3097607-3097852 [Burkholderia pyrrocinia]
ATGTCGCGAAACACATCCGTTTCCCTGGGCGACCACTTTGCCGAATTTGTCGACGCTCAAGTGCAATCGGGGCGATACGG
TTCCGCAAGCGACGTCGTGCGAGCCGGTTTGCGGCTCCTCGAGTCGCACGAAACGCAAATGCGTGCGTTGCAAGAAGCGT
TGAAGGCCGGTGAGGCATCAGGGGCGCCCAAGCCATTCGACAGCAAGGCCTTCCTGGTCCGCATGCGGGCCACGCATGGC
GGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3WTK1

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3WRD7

References