Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3090996..3091672 Replicon chromosome
Accession NZ_CP011503
Organism Burkholderia pyrrocinia strain DSM 10685

Toxin (Protein)


Gene name vagD Uniprot ID A0A0J5X1U9
Locus tag ABD05_RS14060 Protein ID WP_027787436.1
Coordinates 3091256..3091672 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1K1RQE9
Locus tag ABD05_RS14055 Protein ID WP_047901212.1
Coordinates 3090996..3091259 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABD05_RS14040 3086521..3088806 + 2286 WP_047900645.1 TonB-dependent siderophore receptor -
ABD05_RS14045 3088890..3089729 + 840 WP_047901211.1 N(5)-hydroxyornithine transformylase PvdF -
ABD05_RS14050 3089729..3090745 + 1017 WP_047900646.1 acetyltransferase -
ABD05_RS14055 3090996..3091259 + 264 WP_047901212.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ABD05_RS14060 3091256..3091672 + 417 WP_027787436.1 PIN domain-containing protein Toxin
ABD05_RS14065 3091721..3092626 - 906 WP_047900647.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
ABD05_RS14070 3092595..3093668 - 1074 WP_047900648.1 hypothetical protein -
ABD05_RS14075 3094011..3095174 + 1164 WP_047900649.1 amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14536.66 Da        Isoelectric Point: 7.8895

>T54349 WP_027787436.1 NZ_CP011503:3091256-3091672 [Burkholderia pyrrocinia]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADLAARGTPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLSLEDWAA

Download         Length: 417 bp

>T54349 NZ_CP011503:3091256-3091672 [Burkholderia pyrrocinia]
GTGACCACGCTCTACATGCTCGATACGAACATTTGTTCGTTCATCATGCGCGAGCGGCCGCCCGTGGTGCTGTCGCGGCT
GCAGTCGTGCGTGAACGCGCAGCACCGGATCGTCGTGTCGGCGATTACCTATGCCGAGATGCGGTTCGGGGCCGTCGGCA
GGAAGGCGTCGCCGAAGCATGCGGAACTCGTGACGGCCTTTGTTTCGCGGCTGGACGGTGTGCTGTCGTGGGATACGGCG
GCCGTCGATGCAACGGCCGCGATTCGCGCGGATCTCGCCGCGCGCGGCACGCCGATCGGTGCGAACGATGCGTCGATCGC
CGGGCATGCAATCGCGGCCGGCGCGGTGCTCGTCACGAACAACGGGCGGGAATTCGGCCGCGTCGCCGGATTGTCGCTCG
AAGACTGGGCGGCCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9716.97 Da        Isoelectric Point: 4.6437

>AT54349 WP_047901212.1 NZ_CP011503:3090996-3091259 [Burkholderia pyrrocinia]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFANEPLADADFLAERPAVIESGRFDLSGDAG
APTESGR

Download         Length: 264 bp

>AT54349 NZ_CP011503:3090996-3091259 [Burkholderia pyrrocinia]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGTGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACGCTGCTGCTGCGCCCCGTGCGCCCCACGTGGCTGTCGTTCGCGAACGAAC
CTCTGGCCGACGCCGATTTCCTCGCCGAACGCCCGGCCGTCATCGAGTCCGGCCGTTTCGACCTGTCCGGCGATGCCGGC
GCGCCGACGGAGTCCGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J5X1U9

Antitoxin

Source ID Structure
AlphaFold DB A0A1K1RQE9

References