Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3547628..3548291 Replicon chromosome
Accession NZ_CP011502
Organism Aeromicrobium erythreum strain AR18

Toxin (Protein)


Gene name vapC Uniprot ID A0A0U4BF22
Locus tag Aeryth_RS16745 Protein ID WP_067860957.1
Coordinates 3547872..3548291 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0U3KP11
Locus tag Aeryth_RS16740 Protein ID WP_067860955.1
Coordinates 3547628..3547870 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Aeryth_RS16715 3543088..3543858 - 771 WP_067860947.1 AraC family transcriptional regulator -
Aeryth_RS16720 3543903..3544325 + 423 WP_067860949.1 DUF2000 domain-containing protein -
Aeryth_RS16725 3544363..3545169 + 807 Protein_3312 NAD(P)/FAD-dependent oxidoreductase -
Aeryth_RS16730 3545568..3546557 - 990 WP_067860951.1 adenylate/guanylate cyclase domain-containing protein -
Aeryth_RS16735 3546554..3547561 - 1008 WP_067860953.1 alpha-hydroxy-acid oxidizing protein -
Aeryth_RS16740 3547628..3547870 + 243 WP_067860955.1 hypothetical protein Antitoxin
Aeryth_RS16745 3547872..3548291 + 420 WP_067860957.1 PIN domain-containing protein Toxin
Aeryth_RS16750 3548293..3549033 - 741 WP_083516526.1 amino acid ABC transporter ATP-binding protein -
Aeryth_RS16755 3549033..3549878 - 846 WP_067861987.1 amino acid ABC transporter permease -
Aeryth_RS16760 3549875..3550741 - 867 WP_067860959.1 ABC transporter substrate-binding protein -
Aeryth_RS16765 3550768..3551052 - 285 WP_067860961.1 hypothetical protein -
Aeryth_RS16770 3551112..3551657 + 546 WP_067860963.1 PadR family transcriptional regulator -
Aeryth_RS17480 3551605..3551856 - 252 WP_083516527.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15117.35 Da        Isoelectric Point: 6.2838

>T54348 WP_067860957.1 NZ_CP011502:3547872-3548291 [Aeromicrobium erythreum]
MDLPDVNVLLALTLREHVHHESAQGWLETVQTFATTPVTEAGLVRLSMNRALTGAAASIDLSLAALRSMRAHPRAVFLPD
DATLAEPHVELTGLVGHRQVTDLHLLNLAALHDARLVTFDTRLAPTLQPADRDRVLTLA

Download         Length: 420 bp

>T54348 NZ_CP011502:3547872-3548291 [Aeromicrobium erythreum]
ATGGACCTCCCCGACGTCAACGTCCTGCTGGCGCTGACCCTGCGGGAGCACGTGCACCACGAGTCCGCCCAGGGCTGGCT
CGAGACGGTCCAGACCTTCGCGACGACGCCCGTCACCGAGGCCGGACTCGTCCGGCTCTCGATGAACCGGGCGCTCACGG
GTGCTGCGGCATCGATCGACCTGAGCCTGGCCGCGCTCCGCAGCATGAGGGCCCATCCGCGCGCCGTCTTCCTCCCCGAC
GACGCCACGCTGGCGGAGCCGCACGTCGAGCTGACCGGCCTCGTCGGGCATCGCCAGGTGACGGACCTGCACCTGCTCAA
CCTCGCCGCGCTGCACGACGCACGCCTGGTCACGTTCGACACGAGGCTGGCACCCACGCTCCAGCCGGCGGACCGCGACC
GCGTGCTGACGCTCGCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8225.29 Da        Isoelectric Point: 3.9652

>AT54348 WP_067860955.1 NZ_CP011502:3547628-3547870 [Aeromicrobium erythreum]
MRTTLSVDPRVLAVARARVAAGLDASIGEAVSALALAGIESTQVRSDPEPSTRNGIVLIPSDPGAPVVTDEMVADLLDEE

Download         Length: 243 bp

>AT54348 NZ_CP011502:3547628-3547870 [Aeromicrobium erythreum]
ATGCGCACCACTCTCAGCGTCGATCCTCGCGTGCTGGCCGTCGCGCGCGCTCGTGTCGCCGCGGGTCTGGACGCGAGCAT
CGGCGAGGCCGTCTCCGCCCTCGCCCTGGCGGGGATCGAGTCCACCCAGGTCCGCTCCGATCCCGAGCCGTCGACGAGGA
ACGGCATCGTCCTGATCCCCTCCGACCCCGGCGCCCCGGTCGTGACCGACGAGATGGTCGCCGACCTGCTCGACGAGGAG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U4BF22

Antitoxin

Source ID Structure
AlphaFold DB A0A0U3KP11

References