Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1605464..1607315 Replicon chromosome
Accession NZ_CP011501
Organism Pandoraea apista strain AU2161

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag AA956_RS07205 Protein ID WP_052765530.1
Coordinates 1605464..1606372 (+) Length 303 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag AA956_RS07210 Protein ID WP_082117814.1
Coordinates 1606374..1607315 (+) Length 314 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA956_RS07180 1600883..1601959 + 1077 WP_042118075.1 porin -
AA956_RS07185 1602361..1603134 + 774 WP_082118012.1 ABC transporter ATP-binding protein -
AA956_RS07190 1603173..1603955 + 783 WP_042114934.1 ABC transporter permease -
AA956_RS07195 1603971..1604765 + 795 WP_042114936.1 SDR family oxidoreductase -
AA956_RS07200 1604807..1605364 + 558 WP_042114937.1 cupin domain-containing protein -
AA956_RS07205 1605464..1606372 + 909 WP_052765530.1 alpha/beta fold hydrolase Toxin
AA956_RS07210 1606374..1607315 + 942 WP_082117814.1 IclR family transcriptional regulator Antitoxin
AA956_RS07215 1607312..1608118 + 807 WP_042114938.1 SDR family oxidoreductase -
AA956_RS07220 1608111..1609763 + 1653 WP_042114940.1 thiamine pyrophosphate-binding protein -
AA956_RS07225 1609756..1610574 + 819 WP_042114941.1 aspartate dehydrogenase -
AA956_RS07230 1610588..1612084 + 1497 WP_042114942.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(53-288)

Antitoxin

Transcription regulator IclR, C-terminal

(168-291)


Sequences

Toxin        


Download         Length: 303 a.a.        Molecular weight: 31363.44 Da        Isoelectric Point: 5.8839

>T54347 WP_052765530.1 NZ_CP011501:1605464-1606372 [Pandoraea apista]
MQAEASLSEVPEDAAVAPLRARLNAFPYRTLATRTGTVGYRCAGAHAEGGMPVVMLHGIGSGAASWLAQFEATGLNAELY
AWDAPGYGQTSNVADAEPHADAYADALEAWLDALGLKRVALVGHSLGAIMATKFASRSPQRVSGLFLCSPAGGYGKADPD
VRVSKRDSRLAMLDKLGPAGMARERSDNLVAPNAADLPRSWVKWNMARVHPAGYRQATHLLSNGDVAGELAQYVAANAGP
VAVAVGAQDAITTPAACQTIADVAGVPLQIIEGAGHASYIETPDVLNAALAAWLERIAAGER

Download         Length: 909 bp

>T54347 NZ_CP011501:1605464-1606372 [Pandoraea apista]
ATGCAAGCCGAAGCCTCACTGTCCGAAGTGCCCGAAGATGCCGCCGTCGCACCGCTGCGCGCGCGTCTGAATGCTTTCCC
GTACCGCACGCTCGCCACGCGTACGGGCACCGTCGGCTATCGCTGCGCTGGCGCGCATGCCGAGGGTGGCATGCCGGTCG
TGATGCTGCACGGCATTGGGTCCGGCGCGGCGTCATGGCTGGCGCAGTTCGAAGCCACAGGGCTTAACGCCGAGCTTTAC
GCGTGGGACGCCCCGGGCTATGGGCAGACGTCGAACGTCGCCGATGCCGAGCCGCATGCCGATGCTTACGCCGACGCGCT
TGAGGCGTGGCTCGATGCCCTGGGGCTCAAGCGTGTCGCTCTCGTTGGCCACTCGCTGGGCGCGATCATGGCGACGAAGT
TTGCGAGCCGCTCCCCGCAGCGTGTGAGTGGACTCTTTCTCTGCTCGCCGGCCGGCGGTTACGGCAAGGCCGATCCGGAC
GTGCGCGTAAGCAAGCGCGATAGCCGTCTGGCGATGCTCGACAAGCTGGGCCCGGCCGGCATGGCCCGCGAGCGCAGCGA
CAATCTCGTCGCGCCGAATGCCGCAGACCTGCCGCGCTCCTGGGTGAAATGGAACATGGCGCGCGTGCATCCCGCCGGAT
ACCGGCAGGCGACGCACCTTCTCTCGAACGGCGACGTCGCCGGCGAGTTGGCGCAATACGTGGCCGCGAACGCCGGGCCG
GTGGCCGTGGCGGTCGGCGCACAGGATGCGATCACGACGCCCGCAGCTTGCCAGACGATTGCCGACGTGGCCGGCGTGCC
ACTGCAGATCATCGAAGGCGCGGGACACGCGTCGTACATCGAAACCCCGGACGTTCTGAACGCCGCGCTCGCGGCGTGGC
TCGAGCGCATCGCGGCAGGAGAGCGCTGA

Antitoxin


Download         Length: 314 a.a.        Molecular weight: 34121.88 Da        Isoelectric Point: 6.3621

>AT54347 WP_082117814.1 NZ_CP011501:1606374-1607315 [Pandoraea apista]
MAPATPKRAAAAPDAQIEDDKLGLQDTQTDGDELAEGSTSDTRYLVPGLERGLRILTQFSPREAVFSAPELSQRLGIPRT
TVFRLLQTLEAMGFLERAGSEKNFRLGVAVLRLGFEYLSSLELTDLGIPIIERLRDATQLTSHIVIRDGRDIVFVAKAQS
VAGVFNSIKVNVGTRLPAHATVHGHVLMGDLTLAELRALYPEKTLEKYTPQTPETLAELFERVREDAERGYAVSASSFER
GISVVSAPVRNDAGRICAAITVTIPRANIDSSMLDAGLIGQVREAADALSHRLNYRPGSDRQPTPYMKSLGLK

Download         Length: 942 bp

>AT54347 NZ_CP011501:1606374-1607315 [Pandoraea apista]
ATGGCACCGGCAACCCCGAAGCGCGCAGCGGCAGCGCCCGACGCGCAGATCGAAGACGACAAGCTCGGTCTTCAGGACAC
CCAGACCGATGGCGACGAACTCGCCGAAGGTTCAACGTCCGACACCCGTTATCTCGTGCCCGGTCTGGAGCGCGGCTTGC
GCATTCTTACGCAGTTCTCGCCGCGCGAGGCCGTATTCAGCGCGCCGGAGTTGTCGCAACGCCTCGGCATTCCGCGTACC
ACCGTTTTCCGTTTGTTGCAGACGCTTGAAGCGATGGGTTTTCTGGAGCGCGCGGGGAGCGAGAAGAATTTCCGTCTGGG
CGTGGCAGTGCTGCGTCTGGGCTTCGAATACCTCAGTTCGCTGGAGTTGACCGATCTGGGGATTCCGATCATCGAACGGC
TGCGCGACGCCACGCAATTGACCTCGCACATCGTGATCCGGGACGGGCGAGACATCGTGTTCGTGGCGAAGGCGCAAAGC
GTTGCCGGCGTTTTCAATTCGATCAAGGTAAACGTCGGCACGCGTCTGCCGGCGCATGCAACGGTGCATGGCCATGTGCT
GATGGGCGACCTGACGCTGGCCGAGCTTCGTGCGCTGTATCCGGAAAAGACGCTAGAAAAATACACGCCGCAAACGCCCG
AGACGCTTGCGGAGTTGTTCGAACGGGTGCGTGAAGACGCCGAGCGCGGTTACGCGGTGTCGGCTTCGTCGTTCGAGCGG
GGCATCAGTGTCGTGAGTGCACCGGTGCGCAACGACGCGGGCCGTATCTGCGCCGCCATCACCGTGACCATTCCGCGCGC
CAACATCGATTCGTCAATGCTCGATGCGGGGCTGATCGGACAGGTGCGCGAGGCGGCCGATGCGCTGTCGCATCGTCTGA
ACTATCGACCGGGCAGCGACCGTCAACCCACCCCCTACATGAAGTCACTGGGATTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References