Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 5121448..5121995 Replicon chromosome
Accession NZ_CP011492
Organism Streptomyces sp. CNQ-509

Toxin (Protein)


Gene name relE Uniprot ID A0A0F7N782
Locus tag AA958_RS22165 Protein ID WP_047017711.1
Coordinates 5121732..5121995 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0F7NAG9
Locus tag AA958_RS22160 Protein ID WP_047017710.1
Coordinates 5121448..5121723 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA958_RS22140 5117133..5118575 - 1443 WP_047017707.1 aldehyde dehydrogenase family protein -
AA958_RS22145 5118592..5119560 - 969 WP_047017708.1 deoxyribose-phosphate aldolase -
AA958_RS22150 5119690..5120373 + 684 WP_047017709.1 PH domain-containing protein -
AA958_RS22155 5120426..5121070 - 645 WP_052770442.1 C40 family peptidase -
AA958_RS22160 5121448..5121723 + 276 WP_047017710.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AA958_RS22165 5121732..5121995 + 264 WP_047017711.1 Txe/YoeB family addiction module toxin Toxin
AA958_RS22170 5122034..5123749 - 1716 WP_047017712.1 phospho-sugar mutase -
AA958_RS22175 5123883..5124689 - 807 WP_047017713.1 purine-nucleoside phosphorylase -
AA958_RS22180 5124791..5126242 + 1452 WP_047017714.1 NAD(P)H-quinone dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10506.90 Da        Isoelectric Point: 9.4577

>T54299 WP_047017711.1 NZ_CP011492:5121732-5121995 [Streptomyces sp. CNQ-509]
MRSVHFDPDGWEDFLFWLASDRKKARRITRLIAEIQRTPFEGIGKPEPLKADLSGYWSRRIDDEHRLVYRADDKEVRILK
ARYHYSD

Download         Length: 264 bp

>T54299 NZ_CP011492:5121732-5121995 [Streptomyces sp. CNQ-509]
ATGCGAAGCGTGCACTTCGACCCTGACGGGTGGGAGGACTTCCTGTTCTGGCTGGCCTCGGACCGGAAGAAGGCCCGAAG
GATCACCCGCCTCATCGCAGAGATCCAGCGCACTCCGTTCGAAGGTATCGGCAAACCTGAACCTCTCAAGGCAGATCTAT
CAGGCTACTGGTCCCGCCGAATCGACGACGAACACCGCCTCGTCTACCGCGCCGATGACAAGGAAGTGAGGATCCTTAAA
GCCCGCTACCACTACAGCGACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9924.10 Da        Isoelectric Point: 4.4550

>AT54299 WP_047017710.1 NZ_CP011492:5121448-5121723 [Streptomyces sp. CNQ-509]
MSISASEARKTLFPLIERVNDDHTPVRITSRSGDAVLMSADDFDAWQETIYLLRSPANARRLMEAVARDKAGSAAVSVSI
DELENMAGGQE

Download         Length: 276 bp

>AT54299 NZ_CP011492:5121448-5121723 [Streptomyces sp. CNQ-509]
ATGTCGATAAGCGCCAGCGAAGCGCGTAAGACCCTCTTCCCGCTCATCGAGCGGGTCAACGACGACCACACTCCCGTACG
CATCACCTCCCGCAGCGGTGACGCGGTGCTGATGTCGGCCGACGACTTCGACGCCTGGCAGGAAACCATCTACCTGCTGC
GCTCCCCGGCCAACGCCCGGCGGCTGATGGAAGCCGTCGCCCGTGACAAGGCGGGTTCCGCCGCGGTCAGCGTCAGTATC
GATGAGCTGGAGAACATGGCAGGCGGACAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F7N782

Antitoxin

Source ID Structure
AlphaFold DB A0A0F7NAG9

References