Detailed information of TA system TA054298

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 912412..913067
• Replicon: chromosome
• Accession: NZ_CP011491
• Organism: Mycolicibacterium vaccae 95051

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: K0VM07
• Locus tag: MYVA_RS04370
• Protein ID: WP_003929786.1
• Coordinates: 912669..913067 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: K0V407
• Locus tag: MYVA_RS04365
• Protein ID: WP_003929787.1
• Coordinates: 912412..912672 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYVA_RS04340	907846..908970	+	1125	WP_040540729.1	hypothetical protein	-
MYVA_RS04345	909028..910179	+	1152	WP_003929791.1	CoA transferase	-
MYVA_RS04350	910270..910851	-	582	WP_003929790.1	zeta toxin family protein	-
MYVA_RS04355	910889..911278	-	390	WP_003929789.1	hypothetical protein	-
MYVA_RS04360	911361..912275	-	915	WP_003929788.1	ribonuclease H	-
MYVA_RS04365	912412..912672	+	261	WP_003929787.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MYVA_RS04370	912669..913067	+	399	WP_003929786.1	type II toxin-antitoxin system VapC family toxin	Toxin
MYVA_RS04375	913172..913828	+	657	WP_204249588.1	response regulator	-
MYVA_RS04380	913825..914271	+	447	WP_003929784.1	response regulator transcription factor	-
MYVA_RS04385	914253..915554	+	1302	WP_003929783.1	two-component sensor histidine kinase	-
MYVA_RS04390	915668..917227	+	1560	WP_003929782.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	861824..913067	51243

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-42)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 13838.72 Da
• Isoelectric Point: 4.4892

>T54298 WP_003929786.1 NZ_CP011491:912669-913067 [Mycolicibacterium vaccae 95051]
VNAAGVLDTSVFIAQESGRSLDSGRIPDEVATTVITLAELNAGVLVAANAETRAQRLATLDAVPDLAALPVDVKAAQMWA
RMRVHLAETGRRVRVNDLWIAAVAASHGLPVVTQDDDFDSLDGVAGLSVIRV

Nucleotide

• Length: 399 bp

>T54298 NZ_CP011491:912669-913067 [Mycolicibacterium vaccae 95051]
GTGAACGCCGCCGGTGTACTCGACACGTCGGTGTTCATCGCCCAGGAAAGCGGTCGATCGCTGGACAGCGGACGCATTCC
GGACGAGGTTGCGACGACGGTCATCACCCTGGCGGAGCTGAACGCGGGGGTCCTGGTCGCCGCCAATGCCGAAACGCGTG
CGCAGCGACTTGCCACCCTGGATGCCGTCCCGGATCTCGCCGCATTGCCCGTGGATGTGAAGGCCGCCCAGATGTGGGCG
CGAATGCGGGTTCATCTTGCCGAGACAGGCCGCCGCGTGCGTGTCAACGATCTGTGGATCGCAGCCGTTGCTGCATCACA
TGGTCTTCCGGTGGTCACCCAAGACGATGACTTCGACTCACTCGACGGCGTCGCCGGATTGAGCGTGATCCGCGTCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9617.86 Da
• Isoelectric Point: 5.1351

>AT54298 WP_003929787.1 NZ_CP011491:912412-912672 [Mycolicibacterium vaccae 95051]
MTEVASRELRNETASLLRRVQAGEDVTITLNGRPVARLVPFEPSRRRWLTRDELISRMRSAQADPGMRDDLAALAGETTD
DLGPIQ

Nucleotide

• Length: 261 bp

>AT54298 NZ_CP011491:912412-912672 [Mycolicibacterium vaccae 95051]
ATGACTGAAGTTGCCTCCCGCGAACTGCGCAACGAAACGGCCAGCTTGCTCCGTCGGGTTCAGGCCGGGGAGGACGTCAC
GATCACACTGAACGGACGCCCAGTTGCGCGTCTGGTGCCCTTCGAGCCATCACGGCGTCGATGGCTCACCAGAGACGAAC
TGATAAGCCGAATGCGCAGCGCCCAAGCTGACCCGGGGATGCGCGATGACCTGGCAGCCCTTGCGGGGGAGACCACCGAC
GATCTCGGGCCGATTCAGTGA

Structures

Toxin

• AlphaFold DB: K0VM07

Antitoxin

• AlphaFold DB: K0V407