Detailed information of TA system TA054297

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/ParD(antitoxin)
• Location: 910270..911278
• Replicon: chromosome
• Accession: NZ_CP011491
• Organism: Mycolicibacterium vaccae 95051

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: K0VBF7
• Locus tag: MYVA_RS04350
• Protein ID: WP_003929790.1
• Coordinates: 910270..910851 (-)
• Length: 194 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: K0UYG8
• Locus tag: MYVA_RS04355
• Protein ID: WP_003929789.1
• Coordinates: 910889..911278 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYVA_RS04335	905953..907680	+	1728	WP_003929793.1	VanW family protein	-
MYVA_RS04340	907846..908970	+	1125	WP_040540729.1	hypothetical protein	-
MYVA_RS04345	909028..910179	+	1152	WP_003929791.1	CoA transferase	-
MYVA_RS04350	910270..910851	-	582	WP_003929790.1	zeta toxin family protein	Toxin
MYVA_RS04355	910889..911278	-	390	WP_003929789.1	hypothetical protein	Antitoxin
MYVA_RS04360	911361..912275	-	915	WP_003929788.1	ribonuclease H	-
MYVA_RS04365	912412..912672	+	261	WP_003929787.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
MYVA_RS04370	912669..913067	+	399	WP_003929786.1	type II toxin-antitoxin system VapC family toxin	-
MYVA_RS04375	913172..913828	+	657	WP_204249588.1	response regulator	-
MYVA_RS04380	913825..914271	+	447	WP_003929784.1	response regulator transcription factor	-
MYVA_RS04385	914253..915554	+	1302	WP_003929783.1	two-component sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	861824..913067	51243

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 194 a.a.
• Molecular weight: 21184.16 Da
• Isoelectric Point: 9.3734

>T54297 WP_003929790.1 NZ_CP011491:c910851-910270 [Mycolicibacterium vaccae 95051]
VKRLDLVVGSNGAGKSTFIELTLAPLLPRSVYVNADEIAKRRWPDDPAGHSYEAARMAAATRAKLIELGESFIAETVFSH
PSKLELLDSAHAADFTVILHAVLIPEELAVQRVRYRVRAGDHDVPESKIRQRYQRLWDLVATAAGRADEATFYDNSAIRG
PRIVAQLAGGIVLGSPRWPAWTPTPLANRWPGG

Nucleotide

• Length: 582 bp

>T54297 NZ_CP011491:c910851-910270 [Mycolicibacterium vaccae 95051]
GTGAAGCGTCTCGATCTCGTCGTCGGGTCCAACGGCGCCGGCAAGTCGACCTTCATCGAGCTGACCCTCGCGCCGCTGTT
GCCGCGCAGCGTCTACGTGAACGCCGACGAGATCGCCAAGCGACGCTGGCCCGACGACCCAGCCGGACACAGCTACGAGG
CGGCGCGGATGGCCGCTGCCACTCGCGCAAAACTCATCGAACTCGGCGAGTCCTTCATCGCCGAGACTGTCTTCTCACAT
CCCTCGAAACTTGAACTCCTCGATTCCGCCCACGCAGCGGACTTCACGGTGATCCTGCACGCGGTGTTGATCCCGGAAGA
GCTTGCCGTGCAACGTGTCCGATACCGCGTGCGAGCCGGAGACCATGACGTCCCCGAATCCAAGATCCGGCAGCGCTATC
AACGGCTATGGGATCTGGTCGCCACCGCGGCCGGACGTGCGGACGAGGCGACGTTCTACGACAACAGCGCGATCCGGGGT
CCACGCATCGTGGCTCAACTTGCCGGCGGAATCGTCCTGGGTTCCCCCAGGTGGCCGGCTTGGACACCGACCCCGCTCGC
CAACCGTTGGCCTGGCGGGTGA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13619.06 Da
• Isoelectric Point: 4.7463

>AT54297 WP_003929789.1 NZ_CP011491:c911278-910889 [Mycolicibacterium vaccae 95051]
MSDTADRVTRIAADLMDSAAAEGARQSRSAKQQLDHWARVGRAVSTQHSVARRRVETALAGDVPLRDLTDEEGVVFNAEI
SAAIQERLASADYGAVLGARGVATVALDEDGEIVQYAPDGSSVRLGRGV

Nucleotide

• Length: 390 bp

>AT54297 NZ_CP011491:c911278-910889 [Mycolicibacterium vaccae 95051]
ATGTCCGACACAGCCGACCGGGTGACCAGGATCGCCGCGGATCTGATGGACAGCGCTGCCGCCGAAGGCGCACGTCAGAG
CCGGTCGGCAAAACAACAGTTGGACCACTGGGCGCGGGTCGGGCGGGCGGTGTCCACTCAGCACAGCGTGGCGCGCCGCA
GGGTGGAAACTGCCCTCGCCGGTGATGTTCCTCTACGGGATCTGACCGACGAGGAAGGGGTCGTATTCAACGCCGAGATC
TCCGCGGCGATCCAGGAACGCCTCGCGAGCGCCGACTACGGGGCGGTACTGGGCGCGCGAGGAGTCGCCACGGTGGCGCT
CGACGAGGATGGCGAGATCGTTCAGTACGCACCAGACGGCAGTTCGGTACGACTGGGCCGCGGTGTGTGA

Structures

Toxin

• AlphaFold DB: K0VBF7

Antitoxin

• AlphaFold DB: K0UYG8