Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 1378251..1379454 Replicon chromosome
Accession NZ_CP011486
Organism Helicobacter pylori strain K26A1

Toxin (Protein)


Gene name panT Uniprot ID A0A1A9HEK8
Locus tag AA977_RS06635 Protein ID WP_064435037.1
Coordinates 1378251..1379027 (-) Length 259 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A1A9HDV1
Locus tag AA977_RS06640 Protein ID WP_064435038.1
Coordinates 1379017..1379454 (-) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA977_RS06625 1375582..1376760 + 1179 WP_064435035.1 L-seryl-tRNA(Sec) selenium transferase -
AA977_RS06630 1376856..1378043 + 1188 WP_064435036.1 transcription termination/antitermination protein NusA -
AA977_RS06635 1378251..1379027 - 777 WP_064435037.1 hypothetical protein Toxin
AA977_RS06640 1379017..1379454 - 438 WP_064435038.1 SocA family protein Antitoxin
AA977_RS06645 1379984..1383559 - 3576 WP_064435039.1 Eco57I restriction-modification methylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(24-119)


Sequences

Toxin        


Download         Length: 259 a.a.        Molecular weight: 30212.47 Da        Isoelectric Point: 9.0196

>T54296 WP_064435037.1 NZ_CP011486:c1379027-1378251 [Helicobacter pylori]
METKEKEKDEKLEKIIALLCKEGDLSSQKDRIIKEFKEIYQGEYRHKYSKITTIILSSTRDKEQAFMTLTQNIRILKEAK
DDKEIEAIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSNKLDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFVV
GLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSRISLSKERKDTQENFCKKSMFCFNLIVIILFVIGFCG
ELHIIQRLVSIYNIKLSF

Download         Length: 777 bp

>T54296 NZ_CP011486:c1379027-1378251 [Helicobacter pylori]
ATGGAAACTAAAGAAAAAGAAAAAGATGAAAAGTTAGAAAAAATTATCGCATTGTTGTGTAAAGAGGGGGATTTGTCTAG
CCAAAAAGATCGAATCATCAAAGAATTCAAAGAAATCTATCAAGGAGAGTATAGGCATAAATATTCAAAAATTACAACTA
TTATTTTAAGCTCCACAAGGGATAAAGAGCAAGCCTTTATGACGCTCACACAAAATATAAGAATACTTAAAGAAGCTAAA
GATGATAAGGAAATTGAAGCCATTAAACCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTAATAAGTTAGATGATCTAAATAAAAACTATAAAAAATTAA
GCGAAGAATTGAATAAGCAACAAACACAATACATAACCATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTTGTG
GGATTGGCGTTTTCCACTTCTGTATTATCAAATATTGACAAAGCGAACGCCTATCGCTTGGTTTTTGTTATGGCTTTTAT
AGCTCTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAGAATATCCTTATCAAAAGAGAGAAAAGACA
CACAAGAAAATTTTTGCAAAAAATCTATGTTTTGTTTTAATCTAATAGTTATAATTCTGTTTGTGATTGGTTTTTGTGGA
GAATTGCATATAATACAGAGATTAGTTTCTATCTATAATATAAAGCTTAGTTTCTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 17389.54 Da        Isoelectric Point: 6.9813

>AT54296 WP_064435038.1 NZ_CP011486:c1379454-1379017 [Helicobacter pylori]
VVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLRKDELETINHSIEKCNKKSYWDLVKESHKEDGAWHKSFKENRKEIINKDWIKQEAKQIDGN

Download         Length: 438 bp

>AT54296 NZ_CP011486:c1379454-1379017 [Helicobacter pylori]
GTGGTCAATACTTTGGAACTAGCAAAATATATTCTTAAGCATTCAAACAAAGAATTAAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTTACAGAGCTTGATTATATTAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GGCCTGTTGCAAGAGAAGTGTATTATGAATACCGCAATTATGGTGCTAATTCTATTGATAAGCCTAAAGAAGAAACGCTC
TCGCAAAATCTTAGAAAAGATGAACTTGAAACCATCAACCACTCTATTGAAAAATGCAATAAAAAGTCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGTGCATGGCATAAAAGCTTCAAAGAAAATAGAAAAGAAATCATTAACAAAGATT
GGATCAAACAAGAAGCCAAACAGATAGATGGAAACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A9HEK8

Antitoxin

Source ID Structure
AlphaFold DB A0A1A9HDV1

References