Detailed information of TA system TA054292

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 398765..399428
• Replicon: chromosome
• Accession: NZ_CP011483
• Organism: Helicobacter pylori strain DU15

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EE66_RS02025
• Protein ID: WP_172795851.1
• Coordinates: 399177..399428 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1A9GZU7
• Locus tag: EE66_RS02020
• Protein ID: WP_064430823.1
• Coordinates: 398765..399142 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EE66_RS01985	393948..394676	+	729	WP_064430820.1	hydrogenase nickel incorporation protein HypB	-
EE66_RS01990	394676..394912	+	237	WP_000335472.1	HypC/HybG/HupF family hydrogenase formation chaperone	-
EE66_RS01995	394940..396052	+	1113	WP_064430821.1	hydrogenase formation protein HypD	-
EE66_RS02000	396003..396524	-	522	WP_064430822.1	hypothetical protein	-
EE66_RS02015	397038..398411	+	1374	Protein_372	hypothetical protein	-
EE66_RS02020	398765..399142	+	378	WP_064430823.1	hypothetical protein	Antitoxin
EE66_RS02025	399177..399428	+	252	WP_172795851.1	YafQ family addiction module toxin	Toxin
EE66_RS02030	399503..400027	-	525	WP_001135623.1	acyl-CoA thioesterase	-
EE66_RS02035	400167..401015	+	849	WP_064430824.1	SDR family oxidoreductase	-
EE66_RS02040	401008..401988	+	981	WP_000921439.1	iron ABC transporter permease	-
EE66_RS02045	401988..402755	+	768	WP_000242356.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-72)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9769.51 Da
• Isoelectric Point: 10.3737

>T54292 WP_172795851.1 NZ_CP011483:399177-399428 [Helicobacter pylori]
MNGFDDSVLNKVILSLRKKEPLDPQFKDHALKGKWKPFRECHLKPDLLLVCQIKKQENTLFLVRLGSHSELFLNHPHNLK
RLN

Nucleotide

• Length: 252 bp

>T54292 NZ_CP011483:399177-399428 [Helicobacter pylori]
TTGAATGGGTTTGATGATAGTGTTTTGAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGATCCACAATTTAA
AGATCATGCTTTAAAGGGAAAGTGGAAACCTTTTAGGGAATGCCACCTGAAACCGGATTTATTGCTTGTCTGTCAAATTA
AAAAACAAGAAAACACCCTTTTTTTAGTAAGGTTGGGCAGTCATAGCGAGCTGTTTTTAAACCACCCACACAACTTAAAA
CGCTTAAACTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14741.61 Da
• Isoelectric Point: 6.9590

>AT54292 WP_064430823.1 NZ_CP011483:398765-399142 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCF
GHETPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVKTQS

Nucleotide

• Length: 378 bp

>AT54292 NZ_CP011483:398765-399142 [Helicobacter pylori]
ATGCCTAACTCTCCCACCAAAAAAGACTACACGCAATACAGCGAAAAACAGCTTTTTAACTTAATCAACCAGTTAGAGCA
AAAGATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGATGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTT
GGGCATGAAACCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTCAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTAAAACTCAATCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1A9GZU7